2020
DOI: 10.1002/adtp.202000014
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Counteracting Muscle Atrophy on Earth and in Space via Nanofluidics Delivery of Formoterol

Abstract: Skeletal muscle atrophy is a critical health problem that affects quality of life and increases morbidity and mortality. At present, exercise training remains the only intervention and pharmaceutical treatments remain elusive. Formoterol (FMT), a 2-adrenergic receptor agonist, has emerged as a potential therapeutic by triggering skeletal muscle anabolism with daily dosing. Here, the efficacy of sustained FMT release is investigated via a subcutaneously implanted nanofluidic delivery system (nF) to prevent musc… Show more

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Cited by 12 publications
(14 citation statements)
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“…Both SiO 2 and SiC showed no difference in thickness before and after implantation, confirming the inertness of the SiC outmost layer. SiC was purposely chosen as a membrane encapsulation layer because it offers biocompatibility and chemical inertness [ 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 ]. We previously demonstrated in vitro its ability to withstand a simulated physiological environment even at accelerated condition (77 °C) for up to 4 months [ 23 ].…”
Section: Resultsmentioning
confidence: 99%
“…Both SiO 2 and SiC showed no difference in thickness before and after implantation, confirming the inertness of the SiC outmost layer. SiC was purposely chosen as a membrane encapsulation layer because it offers biocompatibility and chemical inertness [ 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 ]. We previously demonstrated in vitro its ability to withstand a simulated physiological environment even at accelerated condition (77 °C) for up to 4 months [ 23 ].…”
Section: Resultsmentioning
confidence: 99%
“…Long-acting controlled therapeutic administration represents a promising strategy for medical conditions requiring repeated daily dosing [ 7 , 8 ]. In view of this, long-acting platforms for sustained drug release have been developed, leading to significant improvements in the management of conditions, such as hormone deficiency and infectious diseases [ 9 , 10 , 11 ]. However, the pathophysiology of most chronic diseases is determined by circadian biological cycles [ 12 ], which have a significant impact on the efficacy of treatment and associated adverse effects [ 13 ].…”
Section: Introductionmentioning
confidence: 99%
“…Among these systems, nanofluidic structures such as nanopores [ 18 , 19 , 20 ], nanoslits [ 21 , 22 , 23 ], and nanochannels [ 24 , 25 , 26 ] exhibit electrokinetic phenomena, such as ion current rectification, ion depletion, and ion gating, through the manipulation of their permselectivity. Due to their molecular feature size, nanofluidic channels can offer precise control of and interaction with charged species, opening the possibility to develop new biomedical devices and therapeutic platforms for personalized medicine as well as chronotherapeutic regimens for chronic and dysfunctional diseases [ 27 , 28 , 29 ]. The active interaction of charged surfaces with aqueous media containing charged species such as ions [ 30 , 31 ], DNA [ 32 , 33 ], proteins [ 7 ], and nanoparticles [ 34 ] permits the implementation of analysis and processing for biosensors, molecular separation techniques, and drug-delivery systems [ 13 , 14 , 27 , 28 , 29 ].…”
Section: Introductionmentioning
confidence: 99%
“…Due to their molecular feature size, nanofluidic channels can offer precise control of and interaction with charged species, opening the possibility to develop new biomedical devices and therapeutic platforms for personalized medicine as well as chronotherapeutic regimens for chronic and dysfunctional diseases [ 27 , 28 , 29 ]. The active interaction of charged surfaces with aqueous media containing charged species such as ions [ 30 , 31 ], DNA [ 32 , 33 ], proteins [ 7 ], and nanoparticles [ 34 ] permits the implementation of analysis and processing for biosensors, molecular separation techniques, and drug-delivery systems [ 13 , 14 , 27 , 28 , 29 ]. This electrostatic interaction results in accumulation of ionic species at the surface of the nanofluidic channels, known as the electrical double layer (EDL).…”
Section: Introductionmentioning
confidence: 99%