Counteraction of oxalate induced nitrosative stress by supplementation of l-arginine, a potent antilithic agent

Viswanathan, Pragasam; Kalaiselvi, Periandavan; Sumitra, Kamalanathan; Srinivasan, Sakthivel; Varalakshmi, P.

doi:10.1016/j.cccn.2004.11.029

Cited by 41 publications

(26 citation statements)

References 41 publications

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“…2,3 Acute and chronic production of CaOx crystals induces lipid peroxidation, and therefore, it has been suggested that this process plays an important role in CaOx stone formation. 3 "Lipid peroxidation" usually refers to the functional impairment of cellular components by reactive oxygen species (ROS) such as superoxide radicals, hydroxyl free radicals, and hydrogen peroxide. 4 The ROS act as mediators of nuclear factor kappa-B (NF-B) activation by inhibitor kappa-b degradation (I-B).…”

mentioning

confidence: 99%

Rapid Communication: Protective Effect of a Nuclear FactorκB Inhibitor, Pyrolidium Dithiocarbamate, in the Kidney of Rats with Nephrolithiasis Induced by Ethylene Glycol

Tuğcu

Özbek

Kemahlı

et al. 2007

Journal of Endourology

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confidence: 99%

Rapid Communication: Protective Effect of a Nuclear FactorκB Inhibitor, Pyrolidium Dithiocarbamate, in the Kidney of Rats with Nephrolithiasis Induced by Ethylene Glycol

Tuğcu

Özbek

Kemahlı

et al. 2007

Journal of Endourology

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“…In addition to this, EPV might have increased the bioavailability of nitric oxide to sequester calcium through the cGMP (3', 5' cyclic guanosine monophosphate) pathway. [36] An increase in urinary phosphate excretion was observed in both the disease control group animals. Elevated urinary phosphate excretion along with oxalate induced stress appears to provide a suitable environment for stone formation by forming calcium phosphate crystals, which epitaxially causes CaOx deposition.…”

Section: Discussionmentioning

confidence: 86%

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Prasad¹

2017

IJGP

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Objective: The present study was aimed to evaluate the antiurolithiatic potential of the ethanolic extract of the seed of Phaseolus vulgaris (EPV). Materials and Methods: Calcium oxalate urolithiasis in male Wistar rats was induced by ethylene glycol (EG) (0.75% v/v) and ammonium chloride (1% w/v) administration in drinking water. Cystone (750 mg/kg, p.o.) was used as a standard drug, and EPV was administered at doses of 200 and 400 mg/kg, p.o. Both preventive and curative effects of EPV were evaluated. Urinary biochemical parameters such as calcium, oxalate, phosphate, uric acid and creatinine; deposition of calcium and oxalate in the kidney; and serum uric acid, creatinine, and blood urea nitrogen (BUN) were assessed. Creatinine clearance was calculated. Oxalate associated oxidative stress in the kidney was assessed by estimating in vivo antioxidant parameters such as lipid peroxidation, superoxide dismutase, catalase, and reduced glutathione. Histopathological studies of the kidney were carried out. Results: In the preventive and curative disease-control groups, urinary excretion of calcium, oxalate, and their deposition in the kidney were significantly increased. Elevated levels of phosphate and uric acid in urine and uric acid, creatinine, and BUN in serum were observed in both the control groups. Creatinine clearance was reduced in the control groups. On treatment with cystone and EPV, all the urinary, serum biochemical, and oxidative stress parameters were reversed to almost normal values. Cystone and EPV significantly restored the in vivo antioxidant enzymes by decreasing the lipid peroxidation in the kidney. This study demonstrated the antiurolithiatic activity of the ethanolic extract of P. vulgaris seeds against EG-induced renal calculi in Wistar rats.

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“…Nitric oxide donors have the capacity to control the intracellular rise in the calcium levels. Thus, the plant extract could effectively control the levels of both the salts by the mechanism, such as inhibiting the oxalate or increasing the bioavailability of NO to sequester calcium through the cGMP pathway (Pragasam et al, 2005).…”

Section: Resultsmentioning

confidence: 99%

Anti-Urolithiatic and Anti-Oxidant Effects of Fenugreek on Ethylene Glycol-Induced Kidney Calculi in Rats

Aziz¹,

Shekha²,

Ismail³

2015

JJBS

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Renal calculi formation is one of the most common urological disorders. Urinary stone disease is a common disease which affects 10-12% of the population in industrialized countries. The objective of the present study is to investigate the antiurolithiatic and antioxidant activity of fenugreek on ethylene glycol-induced urolithiasis in rats. Twenty male rats weighing 203-263 were used for this study. Group A animals received distilled water for 28 days. Group B to group D animals received 1% v/v ethylene glycol in distilled water for 28 days. Groups C and D received cystone and fenugreek, respectively, from day 15 to day 28. On day 28, blood was collected for serum malondialdehyde (MDA) and calcium level monitoring. Kidneys of rats from all the groups were removed, and histopathologically examined using Paraffin method. Samples of kidney were viewed under a scanning electron microscope. Histologically, the kidney of fenugreek treated group appeared mostly to be calculi-free, even better than the cystone treated group. Similarly, the calcium oxalate deposits, the serum (MDA), the renal tissue calcium content were all significantly lower than those in the other groups. The results of the present study suggest that fenugreek has a strong antiurolithiatic and antioxidant activity.

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Counteraction of oxalate induced nitrosative stress by supplementation of l-arginine, a potent antilithic agent

Cited by 41 publications

References 41 publications

Rapid Communication: Protective Effect of a Nuclear FactorκB Inhibitor, Pyrolidium Dithiocarbamate, in the Kidney of Rats with Nephrolithiasis Induced by Ethylene Glycol

Rapid Communication: Protective Effect of a Nuclear FactorκB Inhibitor, Pyrolidium Dithiocarbamate, in the Kidney of Rats with Nephrolithiasis Induced by Ethylene Glycol

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Anti-Urolithiatic and Anti-Oxidant Effects of Fenugreek on Ethylene Glycol-Induced Kidney Calculi in Rats

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