Counteraction of oxidative damage in the rat liver by an ancient grain (Kamut brand khorasan wheat)

Benedetti, Serena; Primiterra, Mariangela; Tagliamonte, Maria Chiara; Carnevali, Andrea; Gianotti, Andrea; Bordoni, Alessandra; Canestrari, Franco

doi:10.1016/j.nut.2011.08.006

Cited by 34 publications

(33 citation statements)

References 28 publications

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“…The oxidative damage-induced via adriamycin in the rat liver was counteracted by Se supplementation (Bordoni et al 2008;Bulucu et al 2009). The higher activity of liver GPx and TrxR observed in the Se-fed animals in the basal conditions partly explains the resistance to the ADR-induced oxidative damage and could reflect their higher Se intake (Benedetti et al 2012). Another study has also shown that Se deficiency was caused by 90 % lower hepatic glutathione peroxidase activity (Fischer et al 1992).…”

Section: Discussionmentioning

confidence: 95%

“…It has also been reported that supplementation with antioxidants in ADR-induced myocardial and hepatic injury has a favourable effect on the tissues (Benedetti et al 2012;Raskovic et al 2011). Recent researches have revealed some potential therapeutic agents, such as Se (Benedetti et al 2012;Dursun and Taskin 2011;Koukay et al 1990;Taskin and Dursun 2012), vitamin E (Koukay et al 1990), NAC (N-acetylcysteine) (Wang et al 2014), a-tocopherol (Chautan et al 1992;Myers et al 1982), quercetin (Chen et al 2013) and L-carnosine (Ozdogan et al 2011) effective in limiting the extent of ADR-induced toxicities, all of which are based on the antioxidant properties of the candidate compound.…”

Section: Discussionmentioning

confidence: 97%

“…Recent researches have revealed some potential therapeutic agents, such as Se (Benedetti et al 2012;Dursun and Taskin 2011;Koukay et al 1990;Taskin and Dursun 2012), vitamin E (Koukay et al 1990), NAC (N-acetylcysteine) (Wang et al 2014), a-tocopherol (Chautan et al 1992;Myers et al 1982), quercetin (Chen et al 2013) and L-carnosine (Ozdogan et al 2011) effective in limiting the extent of ADR-induced toxicities, all of which are based on the antioxidant properties of the candidate compound. We have already suggested the selenium to be a possible candidate to eliminate its mitochondrial toxicity in heart and kidney (Taskin and Dursun 2012) tissues.…”

Section: Discussionmentioning

confidence: 99%

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Recovery of adriamycin induced mitochondrial dysfunction in liver by selenium

Taşkın

Dursun

2014

Cytotechnology

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Adriamycin (ADR) is a chemotherapeutic drug. Its toxicities may associate with mitochondriopathy. Selenium (Se) is a trace element for essential intracellular antioxidant enzymes. However, there is lack of data related to the effect of selenium on the liver tissue of ADR-induced mitochondrial dysfunction. The study was to investigate whether Se could restore mitochondrial dysfunction of liver-exposed ADR. Rats were divided into four groups as a control, ADR, Se, co-treated ADR with Se groups. The biochemical measurements of the liver were made in mitochondrial and cytosol. ATP level and mitochondria membrane potential (MMP) were measured. Total oxidant (TOS), total antioxidant (TAS) status were determined and oxidative stress index (OSI) was calculated by using TOS and TAS. ADR increased TOS in mitochondria and also oxidative stress in mitochondria. ADR sligtly decreased MMP, and ATP level. Partial recovery of MMP by Se was able to elevate the ATP production in cotreatment of ADR with Se. TOS in mitochondria and cytosol was diminished, as well as OSI. We concluded that selenium could potentially be used against oxidative stress induced by ADR in liver, resulting from the restoration of MMP and ATP production and prevention of mitochondrial damage in vivo.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

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Recovery of adriamycin induced mitochondrial dysfunction in liver by selenium

Taşkın

Dursun

2014

Cytotechnology

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“…In whole grain there are several types of antioxidant compounds with different structures and types of action. They assist in antioxidants indirectly by way of cofactors such as Iron, Zinc, Copper and Selenium, and directly as antioxidants by way of antioxidant compounds, such as ferulic acid, other polyphenols, carotenoids and vitamin E. It is assumed that they act in a synergistic way and that the antioxidant properties of each whole grain-based product rely on its peculiar antioxidant profile [4].…”

Section: Introductionmentioning

confidence: 99%

“…In two previous studies [4,8], after 7 weeks of experimental diets which were based on either ancient or modern wheat bread, with or without sourdough fermentation, rats from these groups were further divided into 2 subgroups, one receiving an oxidative stress agent by doxorubicin injection. The highest protective effect against oxidative stress was seen in KAMUT ® khorasan bread fed animals, compared to modern wheat bread fed animals, especially when a KAMUT ® sourdough bread was supplied.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of antioxidative and diabetes-preventive properties of an ancient grain, KAMUT® khorasan wheat, in healthy volunteers

Trozzi¹,

Raffaelli

Vignini

et al. 2017

Eur J Nutr

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Purpose Recently, there was an increasing interest on the use of ancient grains because of their better health-related composition. The aim of this study was to evaluate in healthy human subjects the antioxidative and diabetes-preventive properties of ancient KAMUT ® khorasan wheat compared to modern wheat. Methods The study was a randomized, non-blind, parallel arm study where the biochemical parameters of volunteers with a diet based on organic whole grain KAMUT ® khorasan products, as the only source of cereal products were compared to a similar replacement diet based on organic whole grain modern durum wheat products. A total of 30 healthy volunteers were recruited and the intervention period lasted 16 weeks. Blood analyses were performed before and after the diet intervention. The effect of KAMUT ® khorasan products on biochemical parameters was analyzed by multiple quantile regression adjusted for age, sex, physical activity and BMI compared to data at baseline. Results Subjects receiving KAMUT ® khorasan products showed a significantly greater decrease of fat mass (b = 3.7%; CI 1.6-5.5; p = 0.042), insulin (b = 2.4 µU/ml; CI 0.2-4.2; p = 0.036) and a significant increase of DHA (b = − 0.52%; CI − 1.1 to − 0.12; p = 0.021). Conclusions Our study provides evidence that a substitution diet with KAMUT ® khorasan wheat products can reduce some markers associated to the development of type-2 diabetes compared to a diet of modern wheat.

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Wheatgrass‐Derived Polysaccharide Has Antiinflammatory, Anti‐Oxidative and Anti‐Apoptotic Effects on LPS‐Induced Hepatic Injury in Mice

Nepali

Lee

et al. 2017

Phytotherapy Research

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Hepatic injury occurs frequently during sepsis, and polysaccharides isolated from plants have been reported to have antiinflammatory and antioxidant effects in various models. However, the effect of wheatgrass-derived polysaccharide (WGP) has not been previously studied. In the present study, we investigated the effect of WGP on lipopolysaccharide (LPS)-induced hepatic injury in mice. Mice were pre-treated with WGP (100 or 200 mg/kg daily for 2 days) and then challenged with LPS (1 mg/kg, intraperitoneal), and sacrificed after 12 h. Wheatgrass-derived polysaccharide decreased serum aminotransferase levels and histological changes as compared with LPS-challenged mice. Wheatgrass-derived polysaccharide also significantly inhibited LPS-induced pro-inflammatory cytokine up-regulation and improved the oxidative status of liver tissues. Furthermore, these effects were found to be mediated by the suppression of the transcriptional activity of nuclear factor-kappa B (NF-κB), due to inhibitions of transforming growth factor beta (TGF-β)-activated kinase (TAK)-1 phosphorylation and inhibition of kappa B (IκB)-α degradation. In addition, WGP inhibited the activations of mitogen-activated protein kinases (MAPKs). Wheatgrass-derived polysaccharide also attenuated hepatic cell death by modulating caspase-3 and apoptosis associated mitochondrial proteins, such as, B-cell lymphoma 2 (Bcl-2) and Bcl-2-associated X (Bax). Taken together, WGP possesses antiinflammatory, anti-oxidant and anti-apoptotic activity and ameliorates LPS-induced liver injury in mice. Copyright © 2017 John Wiley & Sons, Ltd.

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Counteraction of oxidative damage in the rat liver by an ancient grain (Kamut brand khorasan wheat)

Cited by 34 publications

References 28 publications

Recovery of adriamycin induced mitochondrial dysfunction in liver by selenium

Recovery of adriamycin induced mitochondrial dysfunction in liver by selenium

Evaluation of antioxidative and diabetes-preventive properties of an ancient grain, KAMUT® khorasan wheat, in healthy volunteers

Wheatgrass‐Derived Polysaccharide Has Antiinflammatory, Anti‐Oxidative and Anti‐Apoptotic Effects on LPS‐Induced Hepatic Injury in Mice

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