The paper looks into the scientific basis of criminalistic analytical-operational knowledge. In criminal proceedings, this type of knowledge is the basis of legal sustainability and credibility of the indictment, criminal investigation and evidence before the court, and for development of public policy in the fight against crime in modern society. The purpose of the paper is to prove that the basis of criminal operational and analytical work is intellectual activity in which the procedures of logical, meaningful, systematic and reasoned, rather than common sense of criminal analysts are strictly followed in the process of acquiring operational knowledge, which includes naming and marking criminal phenomena, processes and events and represents a logical basis for understanding the analytical process in criminalistics. In criminalistic operational-analytical research, accurate, relative and applicable knowledge is gained about a certain subject from the criminal milieu, by applying adequate criminalistic and other research methods, which fulfills two essential preconditions of this type of research, primarily the determined object of criminalistic operational research and verified methods of true or at least probable knowledge. The methodology of the research subject in this paper required the application of the operational method of document content analysis in conjunction with hypothetical-deductive and statistical methods, as well as basic analytical-synthetic methods of knowledge. The research results provided a scientifically based theoretical-methodological view of criminalistic analytics and its end product criminalistic, operational-intervention and operational-instructive knowledge that will be helpful to criminalistic and other analysts and researchers in various state institutions and organizations that have a developed criminalistic-analytical and investigative activity in their organizational structure.