2004
DOI: 10.1111/j.1365-2869.2004.00412.x
|View full text |Cite
|
Sign up to set email alerts
|

Counterpointing the functional role of the forebrain and of the brainstem in the control of the sleep–waking system

Abstract: SUMMAR Y This paper reviews the lifetime contributions of the author to the field of sleepwakefulness (S-W), reinterprets results of the early studies, and suggests new conclusions and perspectives. Long-term cats with mesencephalic transection show behavioral/polygraphic rapid eye movement sleep (REMS), including the typical oculopupillary behavior, even when the section is performed in kittens prior to S-W maturation. REMS can be induced as a reflex. Typical non-rapid eye movement S (NREMS) is absent and ful… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

1
46
1
1

Year Published

2005
2005
2015
2015

Publication Types

Select...
5
4

Relationship

0
9

Authors

Journals

citations
Cited by 70 publications
(49 citation statements)
references
References 158 publications
(224 reference statements)
1
46
1
1
Order By: Relevance
“…12, 24, 33, 46, 53, 69, 70, 79), as the lesion differentially affected the circadian distribution of these states. In addition, our findings concur with the proposal that these triggering mechanisms lie elsewhere than in the NPY-sensitive MBH neurons (59,76,91) since these sleep-wake states themselves were not abolished by the NPY-SAP lesion. Moreover, our findings indicate that these lesions did not alter the total amount of wake, NREMS, or REMS under any of the conditions we tested, suggesting that the mechanisms underlying homeostatic control of total sleep time are distinct from those controlling its circadian distribution, and further, that the homeostatic control of total sleep time does not require MBH NPY-sensitive neurons.…”
Section: Discussionsupporting
confidence: 81%
“…12, 24, 33, 46, 53, 69, 70, 79), as the lesion differentially affected the circadian distribution of these states. In addition, our findings concur with the proposal that these triggering mechanisms lie elsewhere than in the NPY-sensitive MBH neurons (59,76,91) since these sleep-wake states themselves were not abolished by the NPY-SAP lesion. Moreover, our findings indicate that these lesions did not alter the total amount of wake, NREMS, or REMS under any of the conditions we tested, suggesting that the mechanisms underlying homeostatic control of total sleep time are distinct from those controlling its circadian distribution, and further, that the homeostatic control of total sleep time does not require MBH NPY-sensitive neurons.…”
Section: Discussionsupporting
confidence: 81%
“…Dorsolateral thalamic areas play significant roles in mediating responses to hypoxia (Koos et al, 1998;Sica et al, 2000). Sleep states functionally reorganize patterning of neural circuitry, particularly in thalamic and hippocampal sites and in forebrain-brainstem interactions, providing a means to dissociate control of breathing from chemoreceptor and metabolic demands (Villablanca, 2004). The findings of more substantial morphological damage in rostral brain areas rather than brainstem sites illustrate the multiplicity of influences on breathing.…”
Section: Hypothalamus Thalamus and Hippocampusmentioning
confidence: 98%
“…Earlier studies in cats with a surgically removed thalamus 16 and more recent studies in rats without a thalamus 17 suggest that thalamic activity may not be critical for maintaining a level of consciousness, as athalamic animals do not seem to be unconscious and can even ambulate. However, these animals seem oblivious to their surroundings, leading to the question of whether they simply have brain arousal in the absence of sensory awareness.…”
Section: Thalamus As "Epiphenomenal" To Anesthetic-induced Unconscioumentioning
confidence: 99%