Counting the cost of critical antibiotic shortages

Khumra, Sharmila; Mahony, Andrew A; Devchand, Misha; Walker, Steven T; Garrett, Kent; Grayson, M Lindsay; Trubiano, Jason A

doi:10.1093/jac/dky410

Cited by 3 publications

(2 citation statements)

References 2 publications

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“…Due to geopolitical unrest and disrupted supply chains, shortages of critical antibiotics have become more common in Australia. 12 Participants in this study noted issues such as supply shortages, challenges with stockpiling, and fluctuations in stock rotation costs in their clinics and local pharmacies. Providing policymakers and those in charge of medicines management with region-specific AMR data can help them assess the need for specific antibiotics to treat their local patient population.…”

Section: Discussionmentioning

confidence: 99%

Responding to the AMR threat: data and information needs of stakeholders working in regional and remote Australia

Eustace,

Hall,

Patel

et al. 2024

ASHE

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Section: Discussionmentioning

confidence: 99%

Responding to the AMR threat: data and information needs of stakeholders working in regional and remote Australia

Eustace,

Hall,

Patel

et al. 2024

ASHE

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“…11 Though not mentioned in the report, the economic loss could be a result of many factors including using higher cost antibiotics, relying on suboptimal therapeutic options leading to more complications and creation of market opportunities for substandard and falsified alternatives. 12 Selecting suboptimal antibiotics can result in drug-resistant infections and contribute…”

Section: Introductionmentioning

confidence: 99%

Shortage of essential antimicrobials: a major challenge to global health security

et al. 2021

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The lack of access to safe and effective antimicrobials for human populations is a threat to global health security and a contributor to the emergence and spread of antimicrobial resistance (AMR). The increasingly common shortages of antimicrobials are an additional threat to the emergence of AMR. While the threat of such drug shortages is most acutely experienced in low-income and middle-income settings, their consequences impact the quality and effectiveness of antimicrobials worldwide. Furthermore, there is a need for robustly conducted studies examining the impact of these increasingly prevalent shortages on patient outcomes and on the emergence and spread of AMR. In this review, we have mapped common drivers for antimicrobial shortages and propose strategies for rethinking the regulation, supply and pricing of antimicrobials to secure their sustainable access across diverse healthcare systems and to help minimise the unintended consequences of weak and ineffective supply chains. Greater government involvement in antimicrobial manufacture and supply is essential to ensure no one is left behind. Dedicated demand systems need to be developed for antimicrobials which take into consideration evolving AMR patterns, burden of diseases, pandemic events and supply and demand issues and facilitate implementation of strategies to address them. Interventions, ranging from advocacy and forecasting to public–private collaborations, new economic models and international consortia working across countries and supply chains, will help assure access to safe and effective antimicrobials to all populations around the globe and ensure that shortages no longer contribute to AMR.

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Antimicrobial Stewardship in Patients with Hematological Malignancies: Key Considerations

2019

Curr Treat Options Infect Dis

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Counting the cost of critical antibiotic shortages

Cited by 3 publications

References 2 publications

Responding to the AMR threat: data and information needs of stakeholders working in regional and remote Australia

Responding to the AMR threat: data and information needs of stakeholders working in regional and remote Australia

Shortage of essential antimicrobials: a major challenge to global health security

Antimicrobial Stewardship in Patients with Hematological Malignancies: Key Considerations

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