Country-Level Factors Dynamics and ABO/Rh Blood Groups Contribution To COVID-19 Mortality

Abstract

Identifying factors related to COVID-19 mortality is important to deploy effective containment measures and to safeguard categories at risk. In the last months, several investigations have tried to ascertain essential features for predicting the COVID-19 mortality tolls depending on country-specific dynamics and population structure. Most studies focused on the initial outbreak of COVID-19 spanning the first half of 2020. Several variables, including obesity, health system indicators such as hospital bed density, and bacillus Calmette-Guerin vaccination have been reported as significantly associated to COVID-19 mortality. Here, we examined in different pandemic stages some of the mentioned associations as well as ABO and Rh blood group indicators, which have also been previously linked to COVID-19 severity and fatal outcome. Using a machine learning approach, we found that the “B+” blood group frequency is an important factor at all stages of the pandemic.

Association of Plasma Metabolites and Lipoproteins with Rh and ABO Blood Systems in Healthy Subjects

“…The ABO and Rh systems, which play a fundamental role in transfusion medicine and hematopoietic transplantation, have been associated to the pathogenesis and pathophysiology of various human diseases, such as cardiovascular − and oncological diseases, , and also have a role in the susceptibility to microorganism, viral, and parasitic infections. − …”

The association of ABO blood group distribution and clinical characteristics in patients with SARS-CoV-2

“…For instance, hemolytic disease of the newborn baby is a real concern when Rh is mismatched between mother and offspring [10]. Recently scientists concluded that the Rh blood type is associated with COVID-19 and Rh negative has a protective role [11]. Therefore, this work aims to investigate the association between the ABO blood group and susceptibility to SARS-CoV-2.…”