Coupled Autoregulation Models

Todem, David; Alzaidi, S.; Chatelin, R.; Farr, Hannah

doi:10.1007/978-3-540-92841-6_470

Cited by 2 publications

(1 citation statement)

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“…Autoregulation plays a very important role in maintaining constant supply of oxygen and other metabolic ingredients to the brain and maintaining constant blood flow in the capillary networks [23]. Consequently, the deterioration of neurovascular autoregulation can have a disruptive effect on cerebral blood flow, leading to brain dysfunction and potentially AD [24].…”

Section: Blood Flow Autoregulationmentioning

confidence: 99%

Modelling of embolus transport and embolic stroke

Sutalo

Bui

Liffman

et al. 2011

Environmental Health and Biomedicine

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Cerebral microembolism may lead to the restriction of blood supply due to damaged blood vessel tissue (focal ischemia) which is increasingly seen as the cause of cognitive deterioration including Alzheimer's disease and vascular dementia. The flow through fractal models of the peripheral vasculature of the Anterior Cerebral Arteries (ACA) and Middle Cerebral Arteries (MCA) was modelled. The multi-scale model of the cerebral vasculature was coupled with blood flow and embolus transport models. The model incorporated asymmetric bifurcation trees, embolus-vascular interactions and autoregulation. Simulations were carried out where the embolus deposition rate, embolus diameter and embolus introduction rate were varied. Increasing the embolus diameter and embolus introduction rate increased the number of blocked terminal arteries to a quasi steady-state. For a low embolus deposition rate the MCA and ACA territory had the same embolization dynamics, even though, the MCA was larger than the ACA. It was also found for a higher embolus deposition rate the MCA, due to its more expansive structure, was less prone to occlusion than the ACA. The results also showed the effect of a single blockage is expected to be less severe in asymmetric flow than symmetric flow. This model will assist in developing a better understanding into embolic stroke and effect of

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Section: Blood Flow Autoregulationmentioning

confidence: 99%