This study proposes an optimal design approach for an inverter-fed permanent magnet synchronous motor (PMSM) considering the variation in motor control parameters and input voltage (inverter output voltage), which vary with respect to the temperature and loading conditions, in an integrated brake system. In an integrated brake system, a quick response to load changes is crucial. Therefore, in this study, to consider the fluctuation in control variables and input voltage, the motor control parameters and input voltage were first calculated according to the operating temperature and loading condition. Subsequently, based on the calculated conditions and the approximated motor input voltage and control parameters, the objective functions corresponding to motor characteristics in transient and steady states were formulated using design-of-experiment (DOE), the moving least square method (MLSM), and the finite element method (FEM). Finally, the optimal design was performed using the genetic algorithm (GA). The validity of the proposed optimal design approach was verified by comparing its optimization results with the FEM analysis results. Thus, it was confirmed that a motor can be designed for an integrated brake system by considering the motor control parameters and motor input voltage, which vary with the driving conditions.