Seasonal weather variations have a profound effect on the integrity of cohesionless soil slopes in the Canadian Prairies owing to the prevalent semi-arid continental climate. The primary contribution of this research is the development of a transient and two-dimensional stability model that is fully coupled with hydraulic and thermal flows. The model was used to predict the factor of safety (FS) for two slope geometries (18 m height and 26 m height) subjected to three weather scenarios (mean, extreme wet, and extreme dry) and four ponding combinations on the upstream and downstream sides of the slopes under no-load and train-load conditions. Results indicated that for mean climate conditions, FS trends fluctuate till April, followed by an increase that remains constant up to November and decreases thereafter. Generally, the FS shows subdued fluctuations and higher values for the high slope compared with the low slope. For wet climate conditions, the FS patterns are similar to mean conditions, albeit with reduced durations of stability during summer. For dry climate conditions, FS values are higher than mean conditions and nearly constant for most of the year. For no ponding and downstream ponding, FS > 1 throughout the year. In contrast, FS > 1 only during the summer (with reduced time in wet climate and extended time in dry climate conditions) for upstream ponding and upstream–downstream ponding. For train loading, FS shows subdued fluctuations and lower values than the corresponding no-loading scenarios for both slopes. The effects of climate conditions and ponding scenarios are further reduced for the high slope. These findings are useful for decision making with regard to the initial design and ongoing performance of natural slopes and embankments in the cohesionless soils of the region.