High-index-contrast, compact microdisk resonators in thermally evaporated As 2 S 3 and Ge 17 Sb 12 S 71 chalcogenide glass films are designed, fabricated using standard UV lithography and characterized. Our pulley coupler configuration demonstrates coupling of the resonators to monolithically integrated photonic wire waveguides without resorting to demanding fine-line lithography. Microdisk resonators in As 2 S 3 support whisperinggallery-mode with cavity quality factors (Q) exceeding 2 × 10 5 , the highest Q value reported in resonator structures in chalcogenide glasses to the best of our knowledge. We have successfully demonstrated a lab-on-a-chip prototype sensor device with the integration of our resonator with planar microfluidic systems. The sensor shows a refractive index sensitivity of 182 nm/RIU (refractive index unit) and a wavelength resolution of 0.1 pm through resonant peak fit. This corresponds to a refractive index detection limit of 8 × 10 -7 RIU at 1550 nm wavelength, which could be further improved