Coupled mother–child model for bioaccumulation of POPs in nursing infants

Trapp, Stefan; Bomholtz, L.M.; Legind, Charlotte Nielsen

doi:10.1016/j.envpol.2007.12.036

Cited by 14 publications

(8 citation statements)

References 24 publications

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“…The same results have been observed in groups of population who present a high intake of milk (i.e. baby infants) (Trapp et al, 2008). Most POPs are banned, severely restricted or carefully managed in industrialized countries; however, some of them are still manufactured and used in developing countries.…”

Section: Environmentally Persistent Pesticidessupporting

confidence: 67%

Dietary Intake of Environmentally Persistent Plaguicides in the European Population

Almeida-González¹,

Boada²,

Zumbado³

et al. 2011

Pesticides - The Impacts of Pesticides Exposure

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Section: Environmentally Persistent Pesticidessupporting

confidence: 67%

Dietary Intake of Environmentally Persistent Plaguicides in the European Population

Almeida-González¹,

Boada²,

Zumbado³

et al. 2011

Pesticides - The Impacts of Pesticides Exposure

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“…Multiple exposure scenarios are relevant to other situations, and tools being developed for this purpose (e.g., Cedergreen et al 2008; Clewell and Gearhardt 2002; Firestone et al 2008; McKinlay et al 2008; Pohl and Abadin 2008; Timchalk and Poet 2008; Trapp et al 2008) may be applicable if situations that include malaria control scenarios are taken into account during their development. Tools that model lactational transfer of compounds will also be useful (Verner et al 2008).…”

Section: Discussionmentioning

confidence: 99%

Malaria Control Insecticide Residues in Breast Milk: The Need to Consider Infant Health Risks

Bouwman

Kylin

2009

Environ Health Perspect

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BackgroundIn many parts of the world, deliberate indoor residual spraying (IRS) of dwellings with insecticides to control malaria transmission remains the only viable option, thereby unintentionally but inevitably also causing exposure to inhabitants. Because mothers are exposed to insecticides via various routes, accumulated residues are transferred to infants via breast milk, in some cases exceeding recommended intake levels. Except for dichlorodiphenyltrichloroethane (DDT), safety of residues of other insecticides in breast milk has not been considered during World Health Organization Pesticide Evaluation Scheme (WHOPES) evaluations. However, very little is known of the health risks posed by these chemicals to infants who, in developing countries, breast-feed for up to 2 years.ObjectiveWe evaluated the need for WHOPES to include breast milk as a potentially significant route of exposure and risk to infants when evaluating the risks during evaluation of IRS insecticides.DiscussionWe present evidence showing that neurologic and endocrine effects are associated with pyrethroids and DDT at levels equal or below known levels in breast milk.ConclusionsBecause millions of people in malaria control areas experience conditions of multiple sources and routes of exposure to any number of insecticides, even though lives are saved through malaria prevention, identification of potential infant health risks associated with insecticide residues in breast milk must be incorporated in WHOPES evaluations and in the development of appropriate risk assessment tools.

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“…Over the same time period, infant adipose tissue and blood TCDD concentrations increased in breastfed infants and decreased in bottle-fed infants. Infant lipids increased with growth, 0.000 0.100 0.200 0.300 0.400 0.500 0.600 0.700 0.800 Australia 2002-2003Austria 1987Belgium 2002Brazil 1992Cambodia 1999Canada 1981-1982Canada 1986China 2007Czech Republic 1998Denmark 1987Faroe Islands 1995Finland 1987France 1990France 1998-1999France 2007Germany 1986-1991Germany 2000-2003Germany 2007-2008Greece 2002-2003Hungary 2007India 2000Indian 2005Ireland 2002Ireland 2010Italy 2007-2008Italy, Seveso 2000-2001Italy, Milan 2000-2001Japan 1993-1994Japan 1998Japan 1999Japan 2001Japan 2002-2005Jordan 1994Korea 1997Latvia 2002Lithuania 1992Malaysia 2003Netherlands 1990-1991Netherlands 1993New Zealand 1988New Zealand 2008No...…”

Section: Toxicokinetics In Infants and Models Of Exposurementioning

confidence: 99%

“…Other models also have found peak exposure of a breastfed infant to occur at about 6 months of age (Trapp et al, 2008). A probabilistic model based on 2000 to 2006 Swedish human milk measurements demonstrated a decline in probabilistic mean TEQ intake from PCDDs/PCDFs from 24.4 pg/kg body weight/day at 1 month of age to 9.6 pg/kg body weight/day at 6 months of age.…”

Section: Toxicokinetics In Infants and Models Of Exposurementioning

confidence: 99%

Agent Orange Exposure and 2,3,7,8‐Tetrachlorodibenzo‐p‐Dioxin (TCDD) in Human Milk

Watkins¹,

Ginevan²

2015

Birth Defects Research Pt B

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Agent Orange was sprayed in parts of southern Vietnam during the U.S.-Vietnam war and was a mixture of two chlorophenoxy herbicides. The mixture was contaminated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). TCDD and other dioxins and furans are measurable in the milk of Vietnamese women. We explored whether the TCDD in milk from these women was from Agent Orange and whether lactational exposure can be a mode of transgenerational effects of TCDD from Agent Orange. A review of the world's literature on milk concentrations of polychlorinated compounds showed the presence of TCDD and other dioxins and furans in all countries that have been assessed. The congener profile of these chemicals, that is, the proportion of different congeners in the sample, can be used to assess the source of milk contamination. Measurements in most countries, including contemporary measurements in Vietnam, are consistent with non-Agent Orange exposure sources, including industrial activities and incineration of waste. Models and supporting human data suggest that TCDD from breastfeeding does not persist in a child past adolescence and that the adult body burden of TCDD is independent of whether the individual was breast- or bottle-fed as a child. These findings suggest that exposure to Agent Orange in Vietnam did not result in persistent transgenerational exposure through human milk.

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Coupled mother–child model for bioaccumulation of POPs in nursing infants

Cited by 14 publications

References 24 publications

Dietary Intake of Environmentally Persistent Plaguicides in the European Population

Dietary Intake of Environmentally Persistent Plaguicides in the European Population

Malaria Control Insecticide Residues in Breast Milk: The Need to Consider Infant Health Risks

Agent Orange Exposure and 2,3,7,8‐Tetrachlorodibenzo‐p‐Dioxin (TCDD) in Human Milk

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