Coupled oxygenation oscillation measured by NIRS and intermittent cerebral activation on EEG in premature infants

Roche-Labarbe, Nadège; Wallois, Fabrice; Bourel-Ponchel, Emilie; Kongolo, G.; Grebe, Reinhard

doi:10.1016/j.neuroimage.2007.04.002

Cited by 90 publications

(80 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To date, there have been only a small number of studies of the hemodynamic correlates of BS and discontinuous electrocortical activity in the animal model 22 and fewer still in human infants. 40 Simultaneous DOT-EEG approaches have the advantage of allowing the investigation of both the temporal and spatial features of the hemodynamic correlate of BS, which may prove essential to understand the relationship between discontinuous EEG states and cerebral function.…”

Section: Discussionmentioning

confidence: 99%

Hemodynamic response to burst-suppressed and discontinuous electroencephalography activity in infants with hypoxic ischemic encephalopathy

et al. 2016

View full text Add to dashboard Cite

Abstract. Burst suppression (BS) is an electroencephalographic state associated with a profound inactivation of the brain. BS and pathological discontinuous electroencephalography (EEG) are often observed in term-age infants with neurological injury and can be indicative of a poor outcome and lifelong disability. Little is known about the neurophysiological mechanisms of BS or how the condition relates to the functional state of the neonatal brain. We used simultaneous EEG and diffuse optical tomography (DOT) to investigate whether bursts of EEG activity in infants with hypoxic ischemic encephalopathy are associated with an observable cerebral hemodynamic response. We were able to identify significant changes in concentration of both oxy and deoxyhemoglobin that are temporally correlated with EEG bursts and present a relatively consistent morphology across six infants. Furthermore, DOT reveals patient-specific spatial distributions of this hemodynamic response that may be indicative of a complex pattern of cortical activation underlying discontinuous EEG activity that is not readily apparent in scalp EEG.

show abstract

Section: Discussionmentioning

confidence: 99%

Hemodynamic response to burst-suppressed and discontinuous electroencephalography activity in infants with hypoxic ischemic encephalopathy

et al. 2016

View full text Add to dashboard Cite

show abstract

“…The neuro-vascular coupling already described in premature infants (31) was sufficiently mature to track brain responses to our stimulation paradigm in bilateral perisylvian channels. HbO increased and Hb decreased shortly after auditory stimulation, with a time course similar to full-term infants and adults (3,32), peaking ∼5-7 s after the stimulus onset (Movie S1; Fig.…”

Section: Hemodynamic Responses To Speech In Preterms' Perisylvian Regmentioning

confidence: 99%

Syllabic discrimination in premature human infants prior to complete formation of cortical layers

Mahmoudzadeh

Dehaene‐Lambertz

Fournier

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

325

239

View full text Add to dashboard Cite

The ontogeny of linguistic functions in the human brain remains elusive. Although some auditory capacities are described before term, whether and how such immature cortical circuits might process speech are unknown. Here we used functional optical imaging to evaluate the cerebral responses to syllables at the earliest age at which cortical responses to external stimuli can be recorded in humans (28-to 32-wk gestational age). At this age, the cortical organization in layers is not completed. Many neurons are still located in the subplate and in the process of migrating to their final location. Nevertheless, we observed several points of similarity with the adult linguistic network. First, whereas syllables elicited larger right than left responses, the posterior temporal region escaped this general pattern, showing faster and more sustained responses over the left than over the right hemisphere. Second, discrimination responses to a change of phoneme (ba vs. ga) and a change of human voice (male vs. female) were already present and involved inferior frontal areas, even in the youngest infants (29-wk gestational age). Third, whereas both types of changes elicited responses in the right frontal region, the left frontal region only reacted to a change of phoneme. These results demonstrate a sophisticated organization of perisylvian areas at the very onset of cortical circuitry, 3 mo before term. They emphasize the influence of innate factors on regions involved in linguistic processing and social communication in humans.hemodynamic response | premature human brain | language | hemispheric lateralization | near infrared spectroscopy S hortly after birth, human infants already exhibit a variety of sophisticated linguistic capacities, from discriminating syllables and human languages (1) to remembering short stories (2). These capacities rely on a set of perisylvian brain areas similar to the one described in adults, involving temporal but also frontal areas (3), with significant asymmetries favoring the left hemisphere at the level of the planum temporale (4, 5). Because audition is already functional during the last months of pregnancy (6), it is still debated whether evolution has endowed humans with a genetically determined cortical organization particularly suitable to process speech or whether fast learning quickly specializes the auditory network toward speech processing during this initial period (7). In the present work, to inform this debate, we examined the functional organization of the perisylvian areas at the onset of cortical circuitry in preterm infants.Neuronal migration is still on its way during the last trimester of human gestation. The majority of the neurons still lie in the subplate, and the six-layered lamination of the cortex becomes fully visible only after 32-wk gestational age (wGA) (8). The first contacts of the thalamo-cortical fibers establish with subplate neurons (9). The first synapses appear in the cortical plate around 26 wGA, with a massive relocation of the afferent fibers from the...

show abstract

“…[28][29][30][31][32][33][34][35] The spontaneous low frequency oscillation (4-150 MHz) in these hemodynamic parameters further re°ects vasomotion in cerebral tissue. 16,[36][37][38] As a totally non-invasive and non-radioactive optical method, NIRS has sub-second temporal resolution and less motion restriction, 39,40 making it a powerful tool for all night sleep study. Although several studies with NIRS repeatedly reported an impairment of cerebral oxygenation in the patients with sleep apnea, [41][42][43][44][45] we still lack knowledge about the changes of cerebral autoregulation mechanism under CPAP therapy.…”

Section: Introductionmentioning

confidence: 99%

Near-infrared spectroscopy (NIRS) as a useful tool to evaluate the treatment efficacy of positive airways pressure therapy in patients with obstructive sleep apnea syndrome (OSAS): A pilot study

Zhang

Schneider

Fritschi

et al. 2014

J. Innov. Opt. Health Sci.

View full text Add to dashboard Cite

In obstructive sleep apnea syndrome (OSA) the periodic reduction or cessation of breathing due to narrowing or occlusion of the upper airway during sleep leads to an impaired cerebral vascular autoregulation that is associated with an increased cardiovascular risk, including stroke. Continuous positive airways pressure (CPAP) therapy at night is the most e®ective treatment for OSA and has been shown to reduce the cardiovascular risk in OSA patients. However, there is no suitable bedside monitoring method evaluating the recovery of cerebral hemodynamics during CPAP therapy. Near-infrared spectroscopy (NIRS) is ideally suited for non-invasive monitoring the cerebral hemodynamics during sleep due to its properties of local measurement, totally safe application and good tolerance to motion. In this pilot study, we monitored cerebral hemodynamics during standard CPAP therapy at night in three patients with severe OSA using NIRS. We found periodic oscillations in HbO 2 , HHb, tissue oxygenation index (TOI) and blood volume (BV) associated with periodic apnea events without CPAP in all OSA patients. These oscillations were eliminated under the optimal CPAP pressures in all patients. These results suggested that the recovery of cerebral hemodynamics impaired by apnea events can be evaluated by bedside NIRS measurements in real time during all night CPAP therapy. NIRS is a useful bedside monitoring tool to evaluate the treatment e±cacy of CPAP therapy in patients with OSA.

show abstract

Coupled oxygenation oscillation measured by NIRS and intermittent cerebral activation on EEG in premature infants

Cited by 90 publications

References 48 publications

Hemodynamic response to burst-suppressed and discontinuous electroencephalography activity in infants with hypoxic ischemic encephalopathy

Hemodynamic response to burst-suppressed and discontinuous electroencephalography activity in infants with hypoxic ischemic encephalopathy

Syllabic discrimination in premature human infants prior to complete formation of cortical layers

Near-infrared spectroscopy (NIRS) as a useful tool to evaluate the treatment efficacy of positive airways pressure therapy in patients with obstructive sleep apnea syndrome (OSAS): A pilot study

Contact Info

Product

Resources

About