Coupled particulate and continuum model for nanoparticle targeted delivery

Tan, Jifu; Wang, Shunqiang; Yang, Jie; Liu, Yaling

doi:10.1016/j.compstruc.2012.12.019

Cited by 32 publications

(24 citation statements)

References 31 publications

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“…Following analysis by Tan etal. and use of a force balance, representative times of T r , T d , and T debond were determined using the expression of total N b to evaluate k a and k d :

k_{a} = \frac{d}{T_{d} + T_{r}} k_{d} = \frac{1}{T_{d e b o n d}}

where d is a representative length, chosen to be the diameter of the particle …”

Section: Methodsmentioning

confidence: 61%

“…Particle adhesion was simulated in a two‐dimensional rectangular channel using COMSOL 5.2 through a combined continuum and particulate model, adapted from previous work and described in detail in the Supporting Information Material . Briefly, a velocity profile was established for an incompressible Newtonian fluid in a rectangular channel with dimensions 10 × 30 μm, with a reactive surface of 10 μm along the bottom wall.…”

Section: Methodsmentioning

confidence: 99%

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Evaluation of receptor‐ligand mechanisms of dual‐targeted particles to an inflamed endothelium

Fromen

Fish

Zimmerman

et al. 2016

Bioengineering & Transla Med

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Vascular‐targeted carriers (VTCs) are designed as leukocyte mimics, decorated with ligands that target leukocyte adhesion molecules (LAMs) and facilitate adhesion to diseased endothelium. VTCs require different design considerations than other targeted particle therapies; adhesion of VTCs in regions with dynamic blood flow requires multiple ligand‐receptor (LR) pairs that provide particle adhesion and disease specificity. Despite the ultimate goal of leukocyte mimicry, the specificity of multiple LAM‐targeted VTCs remains poorly understood, especially in physiological environments. Here, we investigate particle binding to an inflamed mesentery via intravital microscopy using a series of particles with well‐controlled ligand properties. We find that the total number of sites of a single ligand can drive particle adhesion to the endothelium, however, combining ligands that target multiple LR pairs provides a more effective approach. Combining sites of sialyl Lewis A (sLeA) and anti‐intercellular adhesion molecule‐1 (aICAM), two adhesive molecules, resulted in ∼3–7‐fold increase of adherent particles at the endothelium over single‐ligand particles. At a constant total ligand density, a particle with a ratio of 75% sLeA: 25% aICAM resulted in more than 3‐fold increase over all over other ligand ratios tested in our in vivo model. Combined with in vivo and in silico data, we find the best dual‐ligand design of a particle is heavily dependent on the surface expression of the endothelial cells, producing superior adhesion with more particle ligand for the lesser‐expressed receptor. These results establish the importance of considering LR‐kinetics in intelligent VTC ligand design for future therapeutics.

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“…Following analysis by Tan etal. and use of a force balance, representative times of T r , T d , and T debond were determined using the expression of total N b to evaluate k a and k d :

k_{a} = \frac{d}{T_{d} + T_{r}} k_{d} = \frac{1}{T_{d e b o n d}}

where d is a representative length, chosen to be the diameter of the particle …”

Section: Methodsmentioning

confidence: 61%

Section: Methodsmentioning

confidence: 99%

Evaluation of receptor‐ligand mechanisms of dual‐targeted particles to an inflamed endothelium

Fromen

Fish

Zimmerman

et al. 2016

Bioengineering & Transla Med

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“…Higher antibody coating density on the 210 nm particles provides a better possibility of enough ligand-receptor bond formation to assure firm attachment of the particles to the ICAM-1 coated surface [10, 47]. In terms of channel geometry, 10% higher NP binding density is observed at bifurcations compared to straight channels.…”

Section: Resultsmentioning

confidence: 99%

Characterization of nanoparticle delivery in microcirculation using a microfluidic device

Thomas

Tan

Liu

2014

Microvascular Research

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This work focuses on the characterization of particle delivery in microcirculation through a microfluidic device. In microvasculature the vessel size is comparable to that of red blood cells (RBCs) and the existence of blood cells largely influences the dispersion and binding distribution of drug loaded particles. The geometry of the microvasculature leads to non-uniform particle distribution and affects the particle binding characteristics. We perform an in vitro study in a microfluidic chip with micro vessel mimicking channels having a rectangular cross section. Various factors that influence particle distribution and delivery such as the vessel geometry, shear rate, blood cells, particle size, particle antibody density are considered in this study. Around 10% higher particle binding density is observed at bifurcation regions of the mimetic microvasculature geometry compared to straight regions. Particle binding density is found to decrease with increased shear rates. RBCs enhance particle binding for both 210 nm and 2 μm particles for shear rates between 200-1600 s−1 studied. The particle binding density increases about 2-3 times and 6-10 times when flowing in whole blood at 25% RBC concentration compared to the pure particle case, for 210 nm and 2 μm particles respectively. With RBCs, the binding enhancement is more significant for 2 μm particles than that for 210 nm particles, which indicates an enhanced size dependent exclusion of 2 μm particles from the channel centre to the cell free layer (CFL). Increased particle antibody coating density leads to higher particle binding density for both 210 nm and 2 μm particles.

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“…Moreover, thermal LBM is utilized to solve energy equation. To incorporate cell in particulate flow [25, 26], SN model is also coupled with pseudopotential LBM. In what follows, these methods and relevant formulations are discussed.…”

Section: Methodsmentioning

confidence: 99%

Modeling thermal inkjet and cell printing process using modified pseudopotential and thermal lattice Boltzmann methods

Sohrabi

Liu

2018

Phys. Rev. E

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Pseudopotential Lattice Boltzmann methods (LBM) can simulate phase transition in high-density ratio multiphase flow systems. If coupled with thermal LBM through equation of state, it can be used to study instantaneous phase transition phenomena with high temperature gradient where only one set of formulations in LBM system can handle liquid, vapor, phase transition, and heat transport. However, at lower temperatures unrealistic spurious current at interface introduce instability and limit its application in real flow system. In this study, we proposed new modifications to LBM system to minimize spurious current which enables us to study nucleation dynamic at room temperature. To demonstrate the capabilities of this approach, thermal ejection process is modeled as one example of a complex flow system. In inkjet printer, a thermal pulse instantly heats up the liquid in microfluidic chamber and nucleate bubble vapor providing pressure pulse necessary to eject droplets at high speed. Our modified method can present a more realistic model of explosive vaporization process since it can also capture high temperature/density gradient at nucleation region. Thermal inkjet technology has been successfully applied for printing cells, but cells are susceptible to mechanical damage or death as they squeeze out of nozzle head. To study cell deformation, spring network model, representing cells, is connected to LBM through immersed boundary method. Looking into strain/stress distribution of cell membrane at its most deformed state, it is found that high stretching rate effectively increase rupture tension. In other word, membrane deformation energy is released thorough creation of multiple smaller nanopores rather than big pores. Overall, concurrently simulating multiphase flow, phase transition, heat transfer, and cell deformation in one unified LB platform, we were able to provide a better insight into bubble dynamic and cell mechanical damage during printing process.

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Coupled particulate and continuum model for nanoparticle targeted delivery

Cited by 32 publications

References 31 publications

Evaluation of receptor‐ligand mechanisms of dual‐targeted particles to an inflamed endothelium

Evaluation of receptor‐ligand mechanisms of dual‐targeted particles to an inflamed endothelium

Characterization of nanoparticle delivery in microcirculation using a microfluidic device

Modeling thermal inkjet and cell printing process using modified pseudopotential and thermal lattice Boltzmann methods

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