Coupled plasma filtration adsorption for the treatment of sepsis or septic shock ： a systematic review and meta-analysis

Abstract

Background: The effect of coupled plasma filtration adsorption(CPFA) for the treatment of sepsis or septic shock is controversial. A systematic review and meta-analysis was performed to evaluate the impact of CPFA on all-cause mortality in patients with sepsis or septic shock.Methods: We searched the PubMed, Cochrane, and Embase databases for randomized controlled trials(RCTs) and cohort studies from inception to the 1st of May 2022. We included studies involving patients (˃14 years) with sepsis or septic shock. All authors reported our primary outcome of all-cause mortality(hospital mortality, 28-day mortality or 30-day mortality). Results were expressed as odds ratio (OR) with accompanying 95% confidence interval (CI).Results: Six studies including 537 patients were included. The primary outcome of this meta-analysis showed that the all-cause mortality was about 54.2% (119/243 in the CPFA group and 172/294 in the control group). There was no statistically significant difference in the all-cause mortality between two groups(odds ratio [OR]=0.75;95% CI, 0.53 to 1.06; P=0.11;Chi2=14.04; I2=64%).Conclusions: The treatment of CPFA failed to decrease all-cause mortality of sepsis or septic shock patients. Further large-scale randomized controlled trials (RCTs) evaluating the ability of this therapy to improve clinical outcomes are still required to confirm these results.