There is a growing push within the social sciences to conduct translational science that not only advances theory but also achieves real world impact. The goals of this paper are (a) to encourage scholars to engage in translational science by conducting research that responds to pressing social challenges, and (b) to provide concrete recommendations on how to incorporate such practices into their research programs. To do this, we bring together perspectives of academics and practitioners who have experience merging science with practice. We begin by defining what translational science is, describing the benefits of engaging in translational science for peace and conflict studies, and highlighting past research that has done this successfully. Next, we describe various aspects of conducting translational science, such as how researchers can partner with nonacademic stakeholders to create social impact and advance scientific theory, and how they can disseminate findings for public impact. We also address key challenges researchers might face when conducting translational research and provide practical tips that social scientists can use to effectively engage in what we coined the “Bruneauian” approach for how to address such challenges. Specifically, we focus on the skills needed for study design and deployment, how researchers can sensitively interact with vulnerable communities, statistical and methodological considerations, logistical challenges, and how to develop relationships with practitioners. Finally, we conclude with a practitioner’s perspective on how to foster these types of relationships.