“…Nevertheless, the scattered light intensity of the Raman scattering spectrum is only about 1/10 6 to 1/10 9 of the Rayleigh scattering, which greatly limits the application and development of this technique . Surface-enhanced Raman scattering (SERS), which was first observed on rough gold and silver surfaces, is an effective means of improving the sensitivity of Raman spectroscopy. , In recent years, SERS has developed rapidly, and has been widely used in analytical, surface, and biological sciences. − …”