2022
DOI: 10.1016/j.celrep.2022.110539
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Coupling between DNA replication, segregation, and the onset of constriction in Escherichia coli

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Cited by 26 publications
(51 citation statements)
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References 73 publications
(119 reference statements)
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“…Similarly, nucleoid separation could also occur in a previous generation. This was showcased in DAPI demographs of the parent strain grown in the richest nutrient conditions, where cells were already born with two separated nucleoids (Figure 3C), as described before 53 .…”
Section: Resultssupporting
confidence: 67%
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“…Similarly, nucleoid separation could also occur in a previous generation. This was showcased in DAPI demographs of the parent strain grown in the richest nutrient conditions, where cells were already born with two separated nucleoids (Figure 3C), as described before 53 .…”
Section: Resultssupporting
confidence: 67%
“…Throughout our analysis, we did not find any direct connection between DNA replication and division events across strains and media, supporting the idea that the DNA replication and cell division cycles operate largely independently. This is important as a wealth of models have been proposed to explain if and how cell division is controlled by DNA replication 13,21,39,44,53,66,67,7780 . DNA replication and cell constriction are, however, indirectly connected by virtue of their dependence on (different aspects of) cell size, which may help explain the appearance of conflicting results across previous studies.…”
Section: Discussionmentioning
confidence: 99%
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“…The initial increase in the amount of FtsN at midcell was accompanied by an increase in the midcell phase signal ( Fig. 1A and B , bottom), indicating the onset of constriction approximately coincided with FtsN midcell recruitment as concluded before ( 16 , 18 , 20 , 40 ).…”
Section: Resultsmentioning
confidence: 64%
“…To investigate the recruitment kinetics of FtsN to the divisome in live cells, we used quantitative fluorescence microscopy of a functional N-terminal fusion of Ypet to FtsN (Ypet-FtsN) ( 40 ). We studied the kinetics of FtsN relative to the formation of the Z ring.…”
Section: Resultsmentioning
confidence: 99%