2021
DOI: 10.3389/fmolb.2021.778778
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Coupling Between Production of Ribosomal RNA and Maturation: Just at the Beginning

Abstract: Ribosomal RNA (rRNA) production represents the most active transcription in the cell. Synthesis of the large rRNA precursors (35S/47S in yeast/human) is achieved by up to hundreds of RNA polymerase I (Pol I) enzymes simultaneously transcribing a single rRNA gene. In this review, we present recent advances in understanding the coupling between rRNA production and nascent rRNA folding. Mapping of the distribution of Pol I along ribosomal DNA at nucleotide resolution, using either native elongating transcript seq… Show more

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Cited by 4 publications
(1 citation statement)
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References 73 publications
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“…The structures of Pol I initiation complex (Pre-Initiation Complex and Initially Transcribing Complex) are now available (Engel et al, 2018). Although Pol I transcription is well known to be regulatable at the initiation level (Blattner et al, 2011; Sadian et al, 2019; Schneider et al, 2007), rRNA synthesis and pre-rRNA processing are, at least partially, controlled during the elongation phase of Pol I transcription (Azouzi et al, 2021; Schneider et al, 2007). A statistical view of Pol I pausing within rDNA was obtained using high-throughput methods such as Net-Seq or CRAC (Clarke et al, 2018; Turowski et al, 2020a).…”
Section: Introductionmentioning
confidence: 99%
“…The structures of Pol I initiation complex (Pre-Initiation Complex and Initially Transcribing Complex) are now available (Engel et al, 2018). Although Pol I transcription is well known to be regulatable at the initiation level (Blattner et al, 2011; Sadian et al, 2019; Schneider et al, 2007), rRNA synthesis and pre-rRNA processing are, at least partially, controlled during the elongation phase of Pol I transcription (Azouzi et al, 2021; Schneider et al, 2007). A statistical view of Pol I pausing within rDNA was obtained using high-throughput methods such as Net-Seq or CRAC (Clarke et al, 2018; Turowski et al, 2020a).…”
Section: Introductionmentioning
confidence: 99%