Coupling of bone resorption and formation by RANKL reverse signalling

Ikebuchi, Yuki; Aoki, Shigeki; Honma, Masashi; Hayashi, Madoka; Sugamori, Yasutaka; Khan, Masud; Kariya, Yutaka; Kato, Genki; Tabata, Yasuhiko; Jm, Penninger; Udagawa, Nobuyuki; Aoki, Kazuhiro; Suzuki, Hiroshi

doi:10.1530/ey.16.5.17

Cited by 8 publications

(8 citation statements)

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“…The search for novel chemicals from Sceletium species has found renewed interest. Recently, Yin et al (2019) performed an extraction of S. tortuosum and isolated sceletorines A and B for the first time with these authors making suggestions on plausible biosynthetic pathways associated with sceletorine production. This kind of information is largely missing in terms of novel alkaloids that become periodically identified in Sceletium samples by different research groups.…”

Section: Analytical Chemistrymentioning

confidence: 99%

Skeletons in the closet? Using a bibliometric lens to visualise phytochemical and pharmacological activities linked to Sceletium, a mood enhancer

Reddy,

Stafford,

Makunga

2024

Front. Plant Sci.

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Plants from the Sceletium genus (Aizoaceae) have been traditionally used for millennia by the Khoe and Khoen people in southern Africa, as an appetite suppressant as well as a mood elevator. In more recent times, this mood-elevating activity has been commercialised in the South African natural products industry for the treatment of anxiety and depression, with several products available both locally and abroad. Research on this species has seen rapid growth with advancements in analytical and pharmacological tools, in an effort to understand the composition and biological activity. The Web of Science (WoS) database was searched for articles related to ‘Sceletium’ and ‘Mesembrine’. These data were additionally analysed by bibliometric software (VOSviewer) to generate term maps and author associations. The thematic areas with the most citations were South African Traditional Medicine for mental health (110) and anxiolytic agents (75). Pioneer studies in the genus focused on chemical structural isolation, purification, and characterisation and techniques such as thin layer chromatography, liquid chromatography (HPLC, UPLC, and more recently, LC-MS), gas chromatography mass spectrometry (GC-MS), and nuclear magnetic resonance (NMR) to study mesembrine alkaloids. Different laboratories have used a diverse range of extraction and preanalytical methods that became routinely favoured in the analysis of the main metabolites (mesembrine, mesembranol, mesembranone, and Sceletium A4) in their respective experimental settings. In contrast with previous reviews, this paper identified gaps in the research field, being a lack of toxicology assays, a deficit of clinical assessments, too few bioavailability studies, and little to no investigation into the minor alkaloid groups found in Sceletium. Future studies are likely to see innovations in analytical techniques like leaf spray mass spectrometry and direct analysis in real-time ionisation coupled with high-resolution time-of-flight mass spectrometry (DART-HR-TOF-MS) for rapid alkaloid identification and quality control purposes. While S. tortuosum has been the primary focus, studying other Sceletium species may aid in establishing chemotaxonomic relationships and addressing challenges with species misidentification. This research can benefit the nutraceutical industry and conservation efforts for the entire genus. At present, little to no pharmacological information is available in terms of the molecular physiological effects of mesembrine alkaloids in medical clinical settings. Research in these fields is expected to increase due to the growing interest in S. tortuosum as a herbal supplement and the potential development of mesembrine alkaloids into pharmaceutical drugs.

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Section: Analytical Chemistrymentioning

confidence: 99%

Skeletons in the closet? Using a bibliometric lens to visualise phytochemical and pharmacological activities linked to Sceletium, a mood enhancer

Reddy,

Stafford,

Makunga

2024

Front. Plant Sci.

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“…Ginsenoside Rc is one of the bioactive components in ginseng with a wide range of physiological activities, such as inhibition of oxidative stress, anti-inflammation, and regulation of glucose metabolism (Lee et al, 2010;Kim et al, 2014;Yu et al, 2017). Ginsenoside Rc also showed anti-atherosclerosis activity.…”

Section: Ginsenoside Rcmentioning

confidence: 99%

Targeting gut microbiota and immune crosstalk: potential mechanisms of natural products in the treatment of atherosclerosis

Jing,

Guo,

Dai

et al. 2023

Front. Pharmacol.

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Atherosclerosis (AS) is a chronic inflammatory reaction that primarily affects large and medium-sized arteries. It is a major cause of cardiovascular disease and peripheral arterial occlusive disease. The pathogenesis of AS involves specific structural and functional alterations in various populations of vascular cells at different stages of the disease. The immune response is involved throughout the entire developmental stage of AS, and targeting immune cells presents a promising avenue for its treatment. Over the past 2 decades, studies have shown that gut microbiota (GM) and its metabolites, such as trimethylamine-N-oxide, have a significant impact on the progression of AS. Interestingly, it has also been reported that there are complex mechanisms of action between GM and their metabolites, immune responses, and natural products that can have an impact on AS. GM and its metabolites regulate the functional expression of immune cells and have potential impacts on AS. Natural products have a wide range of health properties, and researchers are increasingly focusing on their role in AS. Now, there is compelling evidence that natural products provide an alternative approach to improving immune function in the AS microenvironment by modulating the GM. Natural product metabolites such as resveratrol, berberine, curcumin, and quercetin may improve the intestinal microenvironment by modulating the relative abundance of GM, which in turn influences the accumulation of GM metabolites. Natural products can delay the progression of AS by regulating the metabolism of GM, inhibiting the migration of monocytes and macrophages, promoting the polarization of the M2 phenotype of macrophages, down-regulating the level of inflammatory factors, regulating the balance of Treg/Th17, and inhibiting the formation of foam cells. Based on the above, we describe recent advances in the use of natural products that target GM and immune cells crosstalk to treat AS, which may bring some insights to guide the treatment of AS.

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“…In the past, topological materials with kagome lattice and honeycomb lattice were studied separately, including nodal‐line semimetals and Weyl semimetals, [ 41–45 ] among which studies on kagome lattices were mainly focused on magnetic materials, such as magnetic Weyl semimetals Co 3 Sn 2 S 2 [ 19,20,46 ] and Fe 3 Sn 2 . [ 47–49 ] Thus, the interplay between the kagome lattice and honeycomb lattice is still in the early stage and needs to be explored on both the analytical model level and materials level.…”

Section: Introductionmentioning

confidence: 99%

Chemical Rules for Stacked Kagome and Honeycomb Topological Semimetals

Zhou,

Yang,

Zhang

et al. 2024

Advanced Materials

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We study the chemical rules for predicting and understanding topological states in stacked kagome and honeycomb lattices in both analytical and numerical ways. Starting with a minimal five‐band tight‐binding model, we sort out all the topological states into five groups, which are determined by the interlayer and intralayer hopping parameters. Combined with the model, we design an algorithm to obtain a series of experimentally synthesized topological semimetals with kagome and honeycomb layers, i.e., IAMX family (IA = Alkali metal element, M = Rare earth metal element, X = Carbon group element), in the inorganic crystal structure database. A follow‐up high‐throughput calculation shows that IAMX family materials are all nodal‐line semimetals and they will be Weyl semimetals after taking spin‐orbit coupling into consideration. To have further insights into the topology of the IAMX family, a detailed chemical rule analysis is carried out on the high‐throughput calculations, including the lattice constants of the structure, intralayer and interlayer couplings, bond strengths, electronegativity, and so on, which are consistent with our tight‐binding model. our study provides a way to discover and modulate topological properties in stacked kagome and honeycomb crystals and offers candidates for studying topology‐related properties like topological superconductors and axion insulators.

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Coupling of bone resorption and formation by RANKL reverse signalling

Cited by 8 publications

References 0 publications

Skeletons in the closet? Using a bibliometric lens to visualise phytochemical and pharmacological activities linked to Sceletium, a mood enhancer

Skeletons in the closet? Using a bibliometric lens to visualise phytochemical and pharmacological activities linked to Sceletium, a mood enhancer

Targeting gut microbiota and immune crosstalk: potential mechanisms of natural products in the treatment of atherosclerosis

Chemical Rules for Stacked Kagome and Honeycomb Topological Semimetals

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