In this paper, the mathematical analysis of a quasilinear parabolic-hyperbolic problem in a multidimensional bounded domain is carried out. In a region p a diffusion-advection-reaction-type equation is set, while in the complementary h ≡ \ p , only advection-reaction terms are taken into account. First, the definition of a weak solution u is provided through an entropy inequality on the whole domain Q by using the classical Kuzhkov entropy pairs and the F. Otto framework to transcribe the boundary conditions on ∂ ∩ ∂ h . Since hp contains the outward characteristics for the first-order operator set in Q h , the uniqueness proof begins by focusing on the behavior of u in the hyperbolic layer and then in the parabolic one where u fulfills a variational equality that takes into account the entered data from Q h . The existence property uses a vanishing-viscosity method.