Coupling of myocardial stress resistance and signalling to voluntary activity and inactivity

Abstract

Data confirm the sensitive coupling of ischaemic tolerance to activity: voluntary running induces cardioprotection that dissipates within 1 week of inactivity yet recovers rapidly upon subsequent activity. While exercise in naïve animals induces a molecular profile characteristic of preconditioning/calorie restriction, only GSK3β and EGFR modulation consistently parallel activity- and inactivity-dependent ischaemic tolerance.

The heartbreak of depression: ‘Psycho-cardiac’ coupling in myocardial infarction

“…Physical stress (eg. wheel-running in naïve mice) induces cardioprotection via the same kinase signaling [55], and our recent unpublished findings suggest that psychological effects of environmental enrichment (placement of a locked running wheel in cages) may similarly boost infarct tolerance in caged mice, coupled with phospho-regulation of the same survival and stress kinases (see preliminary data in Fig. 3).…”

Association of Exercise Preconditioning With Immediate Cardioprotection

“…To more directly examine this topic, one study found that 2-weeks of running exercise in mice was associated with increased myocardial tolerance against ischemiareperfusion injury. 62 (Figure 2).…”

Regulation of theβ-Adrenergic Receptor Signaling Pathway in Sustained Ligand-Activated Preconditioning

“…Myocardial Protein Expression Analyses. To examine changes in protein expression, phosphorylation, and localization, cardiac tissue fractions were assessed using western blotting as previously described (Budiono et al, 2016). Left ventricles were isolated and frozen in liquid N 2 before storage at 280°C.…”