Coupling of therapeutic molecules onto surface modified coralline hydroxyapatite

Murugan, R.; Ramakrishna, Seeram

doi:10.1016/j.biomaterials.2003.09.089

Cited by 79 publications

(52 citation statements)

References 27 publications

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“…Perubahan pola XRD pada CHAp 6 jam dan CHAp 24 jam mengindikasikan terbentuknya fase baru sebagai hasil dari proses konversi melalui sonikasi. Setelah proses konversi, terbentuk pola khas dari CHAp pada posisi 26°, 29°, 32°sampai dengan 34°, 40°, dan 46°sampai dengan 54° (Sivakumar et al 1996;Liu, W;Wang, T;Shen, Y;Pan, H;Peng, S;Lu 2013;Murugan and Ramakrishna 2004). Variasi waktu sonikasi berpengaruh pada intensitas puncak yang dihasilkan.…”

Section: Gambar 5 Pola Difraksi Sinar-x Dari Goniopora Danunclassified

Konversi Koral Laut Menjadi Hidroksiapatit Dengan Metode Sonikasi

2017

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ABSTRAK KONVERSI KORAL LAUT MENJADI HIDROKSIAPATIT DENGAN METODE SONIKASI.Sintesis coralline hydroxyapatite (CHAp) dari koral laut yang umumnya menggunakan metode basah yaitu hidrotermal yang memerlukan suhu dan tekanan tinggi. Tujuan dari penelitian ini adalah mengkonversi koral laut Goniopora sp. menjadi CHAp dengan metode sonikasi pada suhu rendah. Goniopora sp. dikalsinasi pada suhu 900°C selama 3 jam, kemudian direaksikan dengan diammonium hidrogen fosfat [(NH4)2HPO4] dan mono kalium fosfat (KH2PO4) dengan waktu sonikasi 6 jam sampai 24 jam pada suhu 60°C. Hasil penelitian menunjukkan bahwa telah terjadi perubahan fase dari koral menjadi CHAp yang dapat dilihat dari identifikasi pola difraksi sinar-X khas dari hidroksiapatit dengan derajat kristalinitas sebesar 66%

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Section: Gambar 5 Pola Difraksi Sinar-x Dari Goniopora Danunclassified

Konversi Koral Laut Menjadi Hidroksiapatit Dengan Metode Sonikasi

2017

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“…A broad peak relating to H 2 O adsorption is noticed at about 3450 cm -1 . The characteristic peak of PO 4 3− group appeared at 1051 cm -1 , which has four distinct vibration modes namely ν 1 , ν 2 , ν 3 and ν 4 in the broad spectrum. The ν 1 and ν 2 vibration peaks are observed at 939 cm -1 and at 479 and 443 cm -1 , respectively.…”

Section: Analysis Of Nanophase Hamentioning

confidence: 99%

“…It is one of the most widely used biomaterials for various bone applications because it possesses most of the qualities required for bone tissue formation. There are a number of methods for processing HA either from natural sources (coral exo-skeleton and animal bone, for example) or from synthetic sources (inorganic chemical synthesis, for example) [8][9][10][11][12] , but these studies focused on conventional microphase HA. Recently, nanophase HA has received much attention owing to its superior surface functional properties over its microphase counterpart, particularly surface area and surface roughness, which are the most imperative properties required to promote cell adhesion and cell-matrix interactions immediately after implantation.…”

Section: Synthesis Of Nanophase Hamentioning

confidence: 99%

“…A suspension of HA seed particles precipitated from the reaction solution was aged for 24h and then subjected to microwave radiation for 15 minutes. The suspension was filtered, washed until there is complete removal of water soluble ammonium chloride (NH 4 Cl 2 ) and dried in a vacuum oven. [15]).…”

Section: Analysis Of Nanophase Hamentioning

confidence: 99%

“…HA is a class of bioceramic material frequently used in bone grafting [2][3][4] and in bone drug delivery [5][6][7] . It is one of the most widely used biomaterials for various bone applications because it possesses most of the qualities required for bone tissue formation.…”

Section: Synthesis Of Nanophase Hamentioning

confidence: 99%

See 2 more Smart Citations

Development of Cell-Responsive Nanophase Hydroxyapatite for Tissue Engineering

Murugan¹,

Ramakrishna²

2007

American J. of Biochemistry and Biotechnology

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Scaffold plays a critical role in engineering bone tissues by providing necessary structural support for the cells to accommodate and guiding their growth in the three dimensional (3D) space. Therefore, designing scaffold that mimic composition and structural aspects of the bone is of great importance to promote cell adhesion, cell-matrix interactions, osteointegration, tissue formation and continued function. Nanophase hydroxyapatite (HA) is a class of bioceramic material that mimics the bone mineral in composition and structure and possesses unique capabilities for surface interactions with biological entities than conventional HA; therefore, it can be used as a scaffolding system in engineering bone tissues. This article reports synthesis, characterization, and evaluation of nanophase HA for use in bone tissue engineering and how the nanophase characteristics help the HA to promote cells/tissue growth with suitable experimental examples.

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Nanophase Biomaterials for Tissue Engineering

Ramalingam

Ramakrishna

2003

Nanotechnologies for the Life Sciences

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The sections in this article are Introduction: Problems with Current Therapies Tissue Engineering: A Potential Solution Stem Cells: The Essentials Nanobiomaterials: A New Generation Scaffolding Material Characteristics of Scaffold Types of Scaffolding Materials Ceramic Nanobiomaterials Polymeric Nanobiomaterials Nanofibrous Scaffold Processing: Current Scenarios Self‐assembly Phase Separation Electrospinning – A New Approach Experimental System Spinning Mechanism Electrospun Nanofibrous Scaffolds Cell–Matrix (Scaffold) Interactions Cell–Ceramic Scaffold Interactions Cell–Polymer Scaffold Interactions Concluding Remarks Acknowledgments

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Coupling of therapeutic molecules onto surface modified coralline hydroxyapatite

Cited by 79 publications

References 27 publications

Konversi Koral Laut Menjadi Hidroksiapatit Dengan Metode Sonikasi

Konversi Koral Laut Menjadi Hidroksiapatit Dengan Metode Sonikasi

Development of Cell-Responsive Nanophase Hydroxyapatite for Tissue Engineering

Nanophase Biomaterials for Tissue Engineering

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