Coupling pH-Regulated Multilayers with Inorganic Surfaces for Bionic Devices and Infochemistry

Ryzhkov, Nikolay V.; Andreeva, Daria V.; Skorb, Ekaterina V.

doi:10.1021/acs.langmuir.9b00633

Cited by 17 publications

(20 citation statements)

References 89 publications

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“…Typically, LbL films are quite thin, but a special design of the so-called exponentially grown films leads to micrometer thick gel-like films [95], which are applicable for tissue engineering. In this regard, the deposition time affects the uptake of polymers [96] and water [97]. The flexibility of the design of LbL coatings enables extensive opportunities including those in tissue engineering, where vascular patches [98] have been designed.…”

Section: Assembly Of Polymers Into Coatings and Films: Hydrogels Lblmentioning

confidence: 99%

Polymer- and Hybrid-Based Biomaterials for Interstitial, Connective, Vascular, Nerve, Visceral and Musculoskeletal Tissue Engineering

2020

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In this review, materials based on polymers and hybrids possessing both organic and inorganic contents for repairing or facilitating cell growth in tissue engineering are discussed. Pure polymer based biomaterials are predominantly used to target soft tissues. Stipulated by possibilities of tuning the composition and concentration of their inorganic content, hybrid materials allow to mimic properties of various types of harder tissues. That leads to the concept of "one-matches-all" referring to materials possessing the same polymeric base, but different inorganic content to enable tissue growth and repair, proliferation of cells, and the formation of the ECM (extra cellular matrix). Furthermore, adding drug delivery carriers to coatings and scaffolds designed with such materials brings additional functionality by encapsulating active molecules, antibacterial agents, and growth factors. We discuss here materials and methods of their assembly from a general perspective together with their applications in various tissue engineering sub-areas: interstitial, connective, vascular, nervous, visceral and musculoskeletal tissues. The overall aims of this review are two-fold: (a) to describe the needs and opportunities in the field of bio-medicine, which should be useful for material scientists, and (b) to present capabilities and resources available in the area of materials, which should be of interest for biologists and medical doctors.Polymers 2020, 12, 620 2 of 30 allows to tailor functionalize the coatings, where their responsiveness to external stimuli is one of their biggest advantages.Polymers stand out as a special class of materials due to the flexibility of design of their blocks and various functionalities, which is brought by their versatile assembly or by introducing additional side-groups or blocks, in the case of block-co-polymers. In this regard, both synthetic and biocompatible polymers are available, and polymer engineering represents a growing area tailoring the needs often driven by applications. With all advantages and the flexibility of the design, there is one significant weakness of polymers-the softness. In regard with tissue engineering, that translates to the fact that some materials can match predominantly soft tissue, but it is difficult to tune mechanical properties of polymers to match the hardness of bones, tendons, etc. And since mechanical properties of materials affect and even drive cell and tissue growth, enhancement of mechanical properties of polymers and biomaterials is essential. Chemical crosslinking can be applied to address these challenges, but that solves problems only partially.To solve these challenges the so-called hybrid materials [6] are used, which possess both inorganic and organic contents. Increasingly, hybrid materials are used in designing the extracellular matrix. The hybrid matrix design for various tissue engineering applications should meet bio-medical requirements. On the one hand, it needs to be biocompatible and biodegradable, which is achieved through the po...

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Section: Assembly Of Polymers Into Coatings and Films: Hydrogels Lblmentioning

confidence: 99%

Polymer- and Hybrid-Based Biomaterials for Interstitial, Connective, Vascular, Nerve, Visceral and Musculoskeletal Tissue Engineering

2020

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“…These effects have found many potential applications, including metal finishing, corrosion chemistry, electrodeposition, electro-organic synthesis, and many others. [6,14,24,[86][87][88][89][90][91] Electrophoretic paint deposition, based on the same local pH change effect, is a particularly important industrial application in producing cars. [92,93] It should be noted that the local (interfacial) pH change can be produced by various means, including photochemical, electrochemical, biocatalytic and microbial processes, while some of them can proceed at non-conducting interfaces and which are not necessary redox reactions, Figure 20.…”

Section: Conclusion Retrospection and Perspectivesmentioning

confidence: 99%

Electrochemically Generated Interfacial pH Change: Application to Signal‐Triggered Molecule Release

2020

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Electron transfer processes during redox reactions are frequently accompanied with protonation/deprotonation processes, thus changing H+/OH− concentrations. When the redox reactions proceed at electrode surfaces, being electrochemically processed, changes in local interfacial pH are possible, particularly when the electrolyte solution is not strongly buffered. The pH gradient can be produced in the diffusion layer and its thickness depends on the rate of electrochemical process, which is measured as the current density, diffusion rates, and buffer capacity. While conventional techniques for measuring pH values are not applicable to a very thin diffusional layer, special methods have been developed for the interfacial pH measurements, including scanning electrochemical microscopy (SECM), rotating ring‐disk electrode (RRDE) measurements, various optical methods, particularly using confocal fluorescent microscopy, and others. Dramatic pH changes proceeding in a near‐electrode layer have been reported for H2O reduction/oxidation, O2 reduction, and some other electrochemical electron/proton transfer processes. These pH changes can be used to trigger some other physical processes, particularly (bio)molecule release processes from modified electrodes, which can be destabilized upon the electrochemically generated pH changes, thus releasing entrapped/loaded target molecules. This review‐type article overviews the formation and analysis of locally produced interfacial pH changes and their use for electrochemically triggered (bio)molecule release. The paper briefly reviews the research area, then concentrating on the systems designed recently by the authors.

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“…The diffusion of oxidation products is highly affected by the structure of the electrode surface [5,6]. Polyelectrolyte modified electrodes are of high interest [7,8]. Layer-by-layer (LbL) polyelectrolyte assemblies containing many charged moieties do not allow ions freely pass through.…”

Section: Introductionmentioning

confidence: 99%

Shannon entropy associated with electrochemically generated ion concentration gradients

Ryzhkov¹,

Yurova²,

Skorb³

2020

Nanosystems: Phys. Chem. Math.

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In this work, we discuss Shannon entropy in relation to ion distribution in solutions. Shannon entropy is a key concept of information theory. Discussion of ion solutions informational entropy is essential for consideration of ions as information carriers in iontronic devices. We studied entropy associated with ions redistribution using model electrochemically triggered local ion fluxes. For this purpose, we utilized bare gold electrodes as well as covered by polyelectrolyte layers and lipids. Modification of the electrode surface leads to a change of ion flux triggered by hydroquinone oxidation. Consequently, various distribution of ions in solution can be obtained. Shannon entropy was evaluated for diverse ion distributions.

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Coupling pH-Regulated Multilayers with Inorganic Surfaces for Bionic Devices and Infochemistry

Cited by 17 publications

References 89 publications

Polymer- and Hybrid-Based Biomaterials for Interstitial, Connective, Vascular, Nerve, Visceral and Musculoskeletal Tissue Engineering

Polymer- and Hybrid-Based Biomaterials for Interstitial, Connective, Vascular, Nerve, Visceral and Musculoskeletal Tissue Engineering

Electrochemically Generated Interfacial pH Change: Application to Signal‐Triggered Molecule Release

Shannon entropy associated with electrochemically generated ion concentration gradients

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