Coupling physical exercise with dietary glucose supplement for treating cognitive impairment in schizophrenia: a theoretical model and future directions

Li, Yuet-Keung; Hui, Christy Lai Ming; H, Lee; Chang, Wing Chung; Chan, Sherry K.W.; Leung, Chung-Ming; Chen, Eric

doi:10.1111/eip.12109

Cited by 9 publications

(9 citation statements)

References 152 publications

(272 reference statements)

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“…A regular exercise program (resistance ? aerobic endurance) elevated serum BDNF levels in schizophrenic patients (Kim et al 2014a); also, glucose supplementation of this program improved cognition and augmented BDNF as well as insulin growth factor-1 (IGF-1) indices (Li et al 2014). In non-affective psychotic disorder patients, 90 min of moderate-to-vigorous exercise per week improved the mental status as well as neurocognition in schizophrenia patients (Firth et al 2015).…”

Section: Exercise-health Benefits In Schizophreniamentioning

confidence: 99%

Physical Exercise Alleviates Health Defects, Symptoms, and Biomarkers in Schizophrenia Spectrum Disorder

Archer

Kostrzewa

2015

Neurotox Res

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Schizophrenia spectrum disorders are characterized by symptom profiles consisting of positive and negative symptoms, cognitive impairment, and a plethora of genetic, epigenetic, and phenotypic biomarkers. Assorted animal models of these disorders and clinical neurodevelopmental indicators have implicated neurodegeneration as an element in the underlying pathophysiology. Physical exercise or activity regimes--whether aerobic, resistance, or endurance--ameliorate regional brain and functional deficits not only in affected individuals but also in animal models of the disorder. Cognitive deficits, often linked to regional deficits, were alleviated by exercise, as were quality-of-life, independent of disorder staging and risk level. Apoptotic processes intricate to the etiopathogenesis of schizophrenia were likewise attenuated by physical exercise. There is also evidence of manifest benefits endowed by physical exercise in preserving telomere length and integrity. Not least, exercise improves overall health and quality-of-life. The notion of scaffolding as the outcome of physical exercise implies the "buttressing" of regional network circuits, neurocognitive domains, anti-inflammatory defenses, maintenance of telomeric integrity, and neuro-reparative and regenerative processes.

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Section: Exercise-health Benefits In Schizophreniamentioning

confidence: 99%

Physical Exercise Alleviates Health Defects, Symptoms, and Biomarkers in Schizophrenia Spectrum Disorder

Archer

Kostrzewa

2015

Neurotox Res

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“…Comprehensive reviews are published on both strategies [22;23;26;28;40]. As such, a brief summary of key mechanisms will be presented for each.…”

Section: Mechanismsmentioning

confidence: 99%

“…The mechanisms underlying the neurocognitive benefits of glucose administration have been postulated to involve the hippocampus and include glucose, insulin, acetylcholine (ACh), and adenosine triphosphate-sensitive potassium channel (K ATP ) regulation [22;37;40]. With oral administration, glucose is able to cross the blood-brain barrier and extracellular glucose is more readily available to replenish hippocampal deficits [37;40].…”

Section: Mechanismsmentioning

confidence: 99%

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Increasing Neuroplasticity to Bolster Chronic Pain Treatment: A Role for Intermittent Fasting and Glucose Administration?

Sibille

Bartsch

Reddy

et al. 2016

The Journal of Pain

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Neuroplastic changes in brain structure and function are not only a consequence of chronic pain but are involved in the maintenance of pain symptoms. Thus, promoting adaptive, treatment responsive neuroplasticity represents a promising clinical target. Emerging evidence about the human brain’s response to an array of behavioral and environmental interventions may assist in identifying targets to facilitate increased neurobiological receptivity, promoting healthy neuroplastic changes. Specifically, strategies to maximize neuroplastic responsiveness to chronic pain treatment could enhance treatment gains by optimizing learning and positive central nervous system (CNS) adaptation. Periods of heightened plasticity have been traditionally identified with the early years of development. More recent research however has identified a wide spectrum of methods that can be used to “re-open” and enhance plasticity and learning in adults. In addition to transcranial direct current stimulation and transcranial magnetic stimulation, behavioral and pharmacological interventions have been investigated. Intermittent fasting and glucose administration are two propitious strategies, which are non-invasive, inexpensive to administer, implementable in numerous settings, and may be applicable across differing chronic pain treatments. Key findings and neurophysiological mechanisms are summarized, providing evidence for the potential clinical contributions of these two strategies toward ameliorating chronic pain.

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“…Among various training protocols, aerobic exercise has been suggested as an effective intervention. Aerobic exercise has been found to have robust (but selective) benefits for executive-control processes in aged people (Colcombe and Kramer, 2003 ), children, and schizophrenia patients and patients suffering from disease (Franco-Martin et al, 2013 ; Sollerhed et al, 2013 ; Li et al, 2014 ; Yau et al, 2014 ). However, little is known whether long-term aerobic exercise training can modulate cognitive inhibition in healthy young adults, a population particularly at risk for a variety of impulsive behaviors.…”

Section: Introductionmentioning

confidence: 99%

Aerobic Exercise As a Potential Way to Improve Self-Control after Ego-Depletion in Healthy Female College Students

et al. 2016

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Purpose: To test whether aerobic exercise can help build self-control stamina in healthy female young adults. Stamina in this context is defined as the capability to endure ego depletion, which can be measured with a self-control task following another activity also requiring self-control.Methods: Forty-five healthy undergraduate women were randomized to either an experimental group or control group. Participants in the experimental group were required to run in their campus running field for 30 min for a period of 5 weeks. Individuals in the control group were required to do diary entries regarding self-control in their daily lives, also for a period of 5 weeks. Before and after the 5-week intervention, participants completed a pain threshold test, a color word Stroop task and the following Cold Pressor Task (CPT) (with and without a distraction component).Results: There was significant decrease of pain tolerance in session 2 relative to session 1 in the control group, but no such decline was found in the experimental group (though the improvement of pain tolerance was not significant), possibly suggesting successful self-control against this kind of decline.Conclusions: Five weeks of aerobic exercise increased self-control after ego depletion in terms of pain tolerance. These findings suggest that aerobic exercise may serve as a potential effective intervention for enhancing self-control in a college female population.

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Coupling physical exercise with dietary glucose supplement for treating cognitive impairment in schizophrenia: a theoretical model and future directions

Cited by 9 publications

References 152 publications

Physical Exercise Alleviates Health Defects, Symptoms, and Biomarkers in Schizophrenia Spectrum Disorder

Physical Exercise Alleviates Health Defects, Symptoms, and Biomarkers in Schizophrenia Spectrum Disorder

Increasing Neuroplasticity to Bolster Chronic Pain Treatment: A Role for Intermittent Fasting and Glucose Administration?

Aerobic Exercise As a Potential Way to Improve Self-Control after Ego-Depletion in Healthy Female College Students

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