Coupling sea lavender (Limonium algarvense Erben) and green tea (Camellia sinensis (L.) Kuntze) to produce an innovative herbal beverage with enhanced enzymatic inhibitory properties

Rodrigues, Maria João; Oliveira, M. Beatriz P.P.; Neves, Vanessa; Ovelheiro, Andreia; Pereira, Catarina; Neng, Nuno R.; Nogueira, J.M.F.; Varela, João; Barreira, Luísa; Custódio, Luísa

doi:10.1016/j.sajb.2017.12.003

Cited by 24 publications

(26 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…ulmifolia leaves exhibit significant anti-AChE activity and suggested that this result can be attributed to the presence of flavonoids and phenolic acids with recognized antioxidant potential in the extract. Rodrigues et al [39] evaluated an another Limonium specie and showed that the infusions and decoctions of L . algarvense flowers powder had high phenolic contents and strong antioxidant activity and capacity to inhibit AChE (IC 50 values of 0.22 to 0.39 mg/mL).…”

Section: Resultsmentioning

confidence: 99%

“…Several authors have also reported that fractions that have the potential to inhibit AChE and are rich in polyphenols might have neuroprotective effects and thus may be used to prevent or postpone the onset of degenerative diseases such as AD [1,2,5,35,39]. This suggests that the EAFs in clusters 1 and 2 should preferably be used in further studies to explore their potential for the treatment of AD since they present better AChE inhibitory activity and higher polyphenol content.…”

Section: Resultsmentioning

confidence: 99%

“…Some authors have suggested that polyphenols, such as astaxanthin, icariin, curcumin, resveratrol, epigallocatechin gallate, and quercetin, as well as extracts with antioxidant activity, can protect SH-SY5Y and PC12 cells against Aβ 25-35- induced cytotoxicity by inhibiting oxidative stress, apoptosis and tau protein hyperphosphorylation; this has been shown to exert a protective effect on learning and memory abilities in rats [7,11,12,19]. The polyphenols are also recognized as potent antioxidants and are responsible for the in vitro anti-AChE effect [37,39,40,45]. Boasquívis et al [42] showed that the synergic effect of the polyphenol constituents of a P .…”

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

In vitro evaluation of the protective effects of plant extracts against amyloid-beta peptide-induced toxicity in human neuroblastoma SH-SY5Y cells

et al. 2019

View full text Add to dashboard Cite

Alzheimer’s disease (AD) is the most common form of dementia and has no cure. Therapeutic strategies focusing on the reduction of oxidative stress, modulation of amyloid-beta (Aβ) toxicity and inhibition of tau protein hyperphosphorylation are warranted to avoid the development and progression of AD. The aim of this study was to screen the crude extracts (CEs) and ethyl-acetate fractions (EAFs) of Guazuma ulmifolia , Limonium brasiliense , Paullinia cupana , Poincianella pluviosa , Stryphnodendron adstringens and Trichilia catigua using preliminary in vitro bioassays (acetylcholinesterase inhibition, antioxidant activity and total polyphenol content) to select extracts/fractions and assess their protective effects against Aβ 25–35 toxicity in SH-SY5Y cells. The effect of the EAF of S . adstringens on mitochondrial membrane potential, lipid peroxidation, superoxide production and mRNA expression of 10 genes related to AD was also evaluated and the electropherogram fingerprints of EAFs were established by capillary electrophoresis. Chemometric tools were used to correlate the in vitro activities of the samples with their potential to be evaluated against AD and to divide extracts/fractions into four clusters. Pretreatment with the EAFs grouped in cluster 1 ( S . adstringens , P . pluviosa and L . brasiliense ) protected SH-SY5Y cells from Aβ 25-35 -induced toxicity. The EAF of S . adstringens at 15.62 μg/mL was able completely to inhibit the mitochondrial depolarization (69%), superoxide production (49%) and Aβ 25-35 -induced lipid peroxidation (35%). With respect to mRNA expression, the EAF of S . adstringens also prevented the MAPT mRNA overexpression (expression ratio of 2.387x) induced by Aβ 25–35 , which may be related to tau protein hyperphosphorylation. This is the first time that the neuroprotective effects of these fractions have been demonstrated and that the electropherogram fingerprints for the EAFs of G . ulmifolia , L . brasiliense , P . cupana , P . pluviosa and S . adstringens have been established. The study expands knowledge of the in vitro protective effects and quality control of the evaluated fractions.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

In vitro evaluation of the protective effects of plant extracts against amyloid-beta peptide-induced toxicity in human neuroblastoma SH-SY5Y cells

et al. 2019

View full text Add to dashboard Cite

show abstract

“…This activity can be due to the volatile compounds from LEO extract, known for their hypoglycaemic potential. For example, Rodrigues et al (2019) suggested that the highest activity against baker's yeast α-glucosidase was observed after the application of individual infusions and decoctions of lavender, with IC 50 values of 0.05 and 0.04 mg mL −1 . Reports on antidiabetic properties of polyphenols are known, thus contributing to the management of oxidative stress-related diseases.…”

Section: Antidiabetic Activitymentioning

confidence: 99%

Combination of freeze drying and molecular inclusion techniques improves the bioaccessibility of microencapsulated anthocyanins from black rice (Oryza sativa L.) and lavender (Lavandula angustifolia L.) essential oils in a model food system

Milea

Dima

Enachi

et al. 2020

Int J of Food Sci Tech

View full text Add to dashboard Cite

Black rice and lavender are promising sources of bioactives, in terms of anthocyanins and essential oils. Their bioaccessibility were improved by microencapsulation, followed by mixing in order to benefit both from colour and flavour, along with radical scavenging and biological properties. The mixed powder showed a satisfactory anthocyanins of 2.55 mg g −1 DW, leading to a radical scavenging activity of 65.14 mmol g −1 DW. The powder displayed an inhibitory effect against α-glucosidase (~49%) and α-amylase (39%), respectively, with a controlled release in intestinal environment. To further examine the functional properties, the powder was added to a food model system. During storage, a release in anthocyanins and flavonoids were found, leading to an increase in radical scavenging activity. The sensorial analysis showed that supplemented biscuits were appreciated for colour and lavender aroma. The obtained results were promising in tailoring the health benefits of secondary metabolites, underutilised in human's nutrition due to their low stability and bioavailability.

show abstract

“…The chemical composition of the lavender extracts or essential oils were studied using the HPLC analysis. The phenolic composition of the infusion or decoction of sea lavender ( Lavandulae algarvense ) was analyzed to confirm the antioxidant and antidiabetic activities [19]. The impact of different storage conditions on the quality of lavender essential oils was also studied using, among others, this method [20].…”

Section: Introductionmentioning

confidence: 99%

Liquid chromatography fingerprint analysis and antioxidant activity of selected lavender species with chemometric calculations

Hawrył

Waksmundzka‐Hajnos

2019

PLoS ONE

View full text Add to dashboard Cite

The extracts of seven Lavandulae species ( Lavandula stoechas , Lavandula lanata , Lavandula viridis , Lavandula angustifolia „Rosea” , Lavandula angustifolia „Afropurpurea” , Lavandula angustifolia and one unknown) were analyzed using the reversed-phase-high performance liquid chromatography–diode array detection (RP-HPLC–DAD) with gradient elution technique to obtain the chromatographic fingerprint profiles. The HPLC analysis was performed using the Kinetex RP18 chromatographic column and eluent consisting of methanol-water-0.1% formic acid (5–100% (v/v)) at 30 °C with the run time of 60 min. and the detection wavelength 280 nm. The chromatograms were preliminary processed with the smoothing, noise reduction, background subtraction and alignment using the SpecAlign program (version 2.4.1). The presence of selected standards (apigenin, myricetin, luteolin, luteolin 7-glucoside, chlorogenic acid, caffeic acid, ferulic acid) in the extracts was confirmed. The chemical similarity between studied plants was evaluated using the Cluster Analysis (Pearson correlation coefficient, r, and Euclidean) and PCA. The preliminary antioxidant activity of studied extracts was evaluated based on the total phenolic content (Folin-Ciocalteu method), ferric ion reducing antioxidant parameter (FRAP) and α,α-diphenyl-β-picrylhydrazyl (DPPH) free radical scavenging method using the spectrophotometric technique.

show abstract

Coupling sea lavender (Limonium algarvense Erben) and green tea (Camellia sinensis (L.) Kuntze) to produce an innovative herbal beverage with enhanced enzymatic inhibitory properties

Cited by 24 publications

References 37 publications

In vitro evaluation of the protective effects of plant extracts against amyloid-beta peptide-induced toxicity in human neuroblastoma SH-SY5Y cells

In vitro evaluation of the protective effects of plant extracts against amyloid-beta peptide-induced toxicity in human neuroblastoma SH-SY5Y cells

Combination of freeze drying and molecular inclusion techniques improves the bioaccessibility of microencapsulated anthocyanins from black rice (Oryza sativa L.) and lavender (Lavandula angustifolia L.) essential oils in a model food system

Liquid chromatography fingerprint analysis and antioxidant activity of selected lavender species with chemometric calculations

Contact Info

Product

Resources

About