Course in Parkinson disease subtypes

Abstract

The three subtypes of Parkinson disease have different courses which are concordant with the differences in brain biochemical abnormalities.

WHOQOL-OLD assessment of quality of life in elderly patients with Parkinson's disease: influence of sleep and depressive symptoms

“…In addition, differences were observed among ART, TDT and MT groups in terms of the WHOQOL-OLD domain 4 scores. Although previous studies have demonstrated that these PD subtypes have different courses, 41,42 ours is the first to show that the level of social participation differs among them.…”

“…4,8,17,42 Therefore, various manifestations can have a negative effect on quality of life. 13,37,38 This underscores the notion that non-motor symptoms should be evaluated.…”

The Parkinson's progression markers initiative (PPMI) – establishing a PD biomarker cohort

“…Baseline MDS‐UPDRS and putamen DAT SBR demonstrated a modest correlation, as in other clinical studies. The lack of correlation may reflect the heterogeneity of presentation, course, and response to therapy, a hallmark of PD 53, 54, 55. The PPMI longitudinal data will examine whether baseline biomarkers and/or short‐term change in baseline biomarkers are predictive of longitudinal PD progression outcomes.…”

Thalamic Deep Brain Stimulation for Parkinson’s Disease

“…It was also noted that severity of tremor does not correlate with severity of dopamine loss or clinical disease progression (Zaidel et al, 2009). Rajput et al (2009) reported that tremor-dominant PD patients showed slower disease progression and less dementia than did akinesia/rigidity-dominant PD patients. A postmortem histopathological study showed that dopaminergic cells in the midbrain retrorubral area, which project to the dorsolateral striatum and ventromedial thalamus, are more severely affected in tremor-dominant PD patients than in akinesia/rigidity-dominant PD patients (Paulus & Jellinger, 1991).…”

“…A recent PET study suggests that the metabolic pattern of tremor-dominant PD is significantly different from that of akinesia/rigidity-dominant PD (Mure et al, 2011). Patients with tremor-dominant PD exhibit better clinical prognoses and slower disease progression with less cognitive decline (Louis et al, 1999;Marras et al, 2002;Rajput et al, 2009). Using FDG-PET, Mure et al (2011) indicated that these clinical findings correlate with a slow deterioration of the metabolic pattern in patients with tremor-dominant PD.…”