Course of coxsackie B antibodies during juvenile diabetes

Abstract

Sera of 83 patients with insulin-dependent diabetes of early onset were tested for latex agglutination-inhibiting antibodies to coxsackie virus types B1-B5. We could not find any evidence of a causal association between Coxsackie B virus infection and diabetes.

Coxsackie B virus serology and Type 1 diabetes mellitus: a systematic review of published case‐control studies

“…In all 26 studies were identified, all of which were case‐control studies. Of these 22 were full papers [5,13–31] (the paper by Banatvala et al . [23] contains three studies) and four were published as letters [12,32–34].…”

“…In all 26 studies were identified, all of which were case-control studies. Of these 22 were full papers [5,[13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31] (the paper by Banatvala et al [23] contains three studies) and four were published as letters [12,[32][33][34]. Figures for the study by Hadden [32] were obtained partly from a published letter by Gamble and Taylor [35].…”

Could the aetiology of IDDM be multifactorial?

“…coxsackie viruses and/or a greater frequency of positive serotests for several enteroviruses when comparing cases and control subjects [5,6,[9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24]. Several of the 'negative' studies deserve comment.…”

“…Several of the 'negative' studies deserve comment. The Irish study [9] included non-insulin-dependent diabetic patients among its 'cases'.Two German studies [12,17] had no control subjects and concluded that coxsackie viruses could not be the aetiologic agent because they could not find evidence of infection in 100 % of cases. Another study tested for antibodies to only three coxsackie serotypes out of 67 known distinct serotypes of enteroviruses [13].…”

“…However, diabetic patients had higher rates for each of the 14 serotypes (p < 0.05 for 8/14 serotypes). The 144 diabetic patients tested positive to a median of 4 serotypes (range [1][2][3][4][5][6][7][8][9][10][11][12][13][14] whereas the 104 control subjects tested positive for a median of 3 serotypes (p = 0.03). Diabetic children 13-18 years of age were more likely than control subjects to be positive for 9 of 14 serotypes (p < 0.05).…”