Course of Disease and Clinical Outcome of Infective Endocarditis in HIV-infected Individuals: A Systematic Review and Meta-analysis

Bos, J.H.; Antonides, Christiaan F J; Barth, Roos E.; Klipstein‐Grobusch, Kerstin; Meel, Ruchika; Vos, Antonie

doi:10.24875/aidsrev.19000117

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2023

2024

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“…A study by Ortega et al in Spain found that the incidence of IDU-IE in persons living with HIV decreased with the advent of highly active antiretroviral therapy [78]. HIV does not seem to worsen the outcomes of IE unless severe immunosuppression is present with an AIDS defining condition and/or CD4+ cell counts <200/microL [79,80]. A general trend corresponding to increased mortality with declining CD4+ count below 500 microL has been observed [81].…”

Section: Hiv Populationmentioning

confidence: 99%

Injection Drug Use-Associated Infective Endocarditis

Barnes¹,

Cook²

2023

Endocarditis - Diagnosis and Treatment

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Injection drug use-associated presents is a unique entity. The demographics of those affected and the clinical presentation are markedly different from those with endocarditis due to other causes. This group presents with a high proportion of right sided valve involvement, distinct pathophysiology, and a more varied array of infectious causes. The best management of these patients regarding medications and surgery remain hotly contested. The increased use of oral antibiotics and novel treatment techniques may expand safe and effective treatment for this group of patients.

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Section: Hiv Populationmentioning

confidence: 99%