Course of longitudinal psychosocial functioning in bipolar youth transitioning to adults

Lee, Erica J.; Hower, Heather; Jones, Richard N.; Birmaher, Boris; Goldstein, Benjamin I.; Merranko, John; Keller, Martin B.; Goldstein, Tina R.; Weinstock, Lauren M.; Dickstein, Daniel P.; Hunt, Jeffrey; Diler, Rasim Somer; Ryan, Neal D.; Gill, Mary Kay; Axelson, David; Yen, Shirley

doi:10.1016/j.jad.2020.03.016

Cited by 11 publications

(10 citation statements)

References 43 publications

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“…Social and school impairment often persisted after symptomatic recovery. In COBY, 40.5% of the patients were impaired in interpersonal functioning and 92.8% in school activities [ 49 ]. A decline in psychosocial functioning was found to precede onset of depressive episodes [ 49 ].…”

Section: Resultsmentioning

confidence: 99%

“…In COBY, 40.5% of the patients were impaired in interpersonal functioning and 92.8% in school activities [ 49 ]. A decline in psychosocial functioning was found to precede onset of depressive episodes [ 49 ]. No decline in cognitive functioning over time was detected within the 2.5 years of follow up [ 42 ].…”

Section: Resultsmentioning

confidence: 99%

“…After initial recovery, 40.5% still had functional impairment in interpersonal relationships and 92.8% in schoolwork. Decline in psychosocial functioning preceded depressive episodes [ 49 ].…”

Section: Figurementioning

confidence: 99%

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What Do We Know about the Long-Term Course of Early Onset Bipolar Disorder? A Review of the Current Evidence

et al. 2021

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Aim: Early onset of psychopathology is often an index of a more severe clinical course and worse prognosis. This review examined the course of bipolar disorder (BD) with onset in childhood and adolescence, with a focus on persistence of symptoms, severity of illness, comorbidity, and functional impairment. Methods: The databases of PubMed, Embase, and PsycInfo were systematically searched for publications since 1990 reporting on long-term (12 months or longer) assessments of patients with early onset BD. Results: Forty-two relevant publications were identified, which reported on data derived from 15 different patient cohorts, including 7 prospective research psychopathology studies, 4 medical record reviews, 2 follow-ups of clinical trial samples, 1 managed care database, and 1 nationwide registry, for a total of 10,187 patients. The length of follow-ups ranged from 1.0 to 15 years. Diagnostic stability of BD ranged from 73% to 100% over ten years. Recovery rate from an index episode was 81.5–100% and recurrence rate was 35–67%. Suicide attempt cumulative prevalence in five years was 18–20%. Earlier age at the first episode predicted a more severe clinical course. Conclusions: Early onset BD persists over time through adolescence, with homotypic diagnostic continuity over the years, but heterogeneity in the severity of the clinical course. Whether early identification and treatment improves distal prognosis remains to be further investigated.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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What Do We Know about the Long-Term Course of Early Onset Bipolar Disorder? A Review of the Current Evidence

et al. 2021

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“…U p to two-thirds of individuals with bipolar disorder have their onset during childhood or adolescence (Perlis et al 2004) Results of a meta-analysis of children and adolescents (N = 56,103) found a weighted average prevalence of 3.9% for the full spectrum of bipolar disorders in youth (bipolar I, II, and not otherwise specified), and a prevalence of 0.6% for bipolar I disorder (Van Meter et al 2019). Childhood onset of bipolar disorder is associated with a more chronic and severe course of illness compared with later onset (Birmaher et al 2006(Birmaher et al , 2014Perlis et al 2009;Lee et al 2020;Post et al 2020). In a long-term (mean, 7.7 years) prospective follow-up study, 76% of children were euthymic for less than 50% of the follow-up period (Lee et al 2020).…”

Section: Introductionmentioning

confidence: 99%

“…Childhood onset of bipolar disorder is associated with a more chronic and severe course of illness compared with later onset (Birmaher et al 2006(Birmaher et al , 2014Perlis et al 2009;Lee et al 2020;Post et al 2020). In a long-term (mean, 7.7 years) prospective follow-up study, 76% of children were euthymic for less than 50% of the follow-up period (Lee et al 2020). In addition to the pervasiveness of abnormal mood states, bipolar disorder in children and adolescents is associated with significant impairment in functioning, cognition, and quality of life (Andreou et al 2013;Bourne et al 2013;Ratheesh et al 2013;Martino et al 2014;Szmulewicz et al 2017;Lima et al 2018).…”

Section: Introductionmentioning

confidence: 99%

Tolerability, Safety, and Effectiveness of Two Years of Treatment with Lurasidone in Children and Adolescents with Bipolar Depression

DelBello

Tocco

Pikalov

et al. 2021

Journal of Child and Adolescent Psychopharmacology

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Objectives: To evaluate long-term safety and effectiveness of lurasidone in children and adolescents with bipolar depression. Methods: Participants, ages 10-17 years, with bipolar depression, who completed 6 weeks of double-blind (DB) treatment with lurasidone or placebo were enrolled in a 2-year, open-label (OL) extension study of lurasidone (20-80 mg/d). The primary effectiveness measure was the Children's Depression Rating Scale, Revised (CDRS-R). Results: A total of 306 participants entered the 2-year extension study; 195 (63.7%) completed 52 weeks, and 168 (54.9%) completed 104 weeks of treatment. For all participants entering the extension study, mean change in CDRS from OL baseline was -13.4 at week 52, and -16.4 at week 104 (-11.3 at last observation carried forward [LOCF]-endpoint). Overall, 31 participants (10.1%) discontinued due to an adverse event (AE); the three most common AEs were headache (23.9%), nausea (16.4%), and somnolence (9.8%). OL treatment with lurasidone was associated with few effects on metabolic parameters or prolactin. Mean change from DB baseline in weight was +4.25 kg at week 52 (vs. an expected weight gain of +3.76 kg), and +6.75 kg at week 104 (vs. an expected weight gain of +6.67 kg), based on the sex-and age-matched United States Center for Disease Control normative data. Conclusions: For youth with bipolar depression, up to 2 years of treatment with lurasidone was generally well tolerated, safe, and effective with relatively low rates of discontinuation due to AEs, minimal effects on weight, metabolic parameters or prolactin, and continued improvement in depressive symptoms. Clinical Trial Registration number: NCT01914393.

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Manische Episode und bipolare affektive Störung

Holtmann,

Wewetzer

2023

Neuro-/Psychopharmaka Im Kindes- Und Jugendalter

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Course of longitudinal psychosocial functioning in bipolar youth transitioning to adults

Cited by 11 publications

References 43 publications

What Do We Know about the Long-Term Course of Early Onset Bipolar Disorder? A Review of the Current Evidence

What Do We Know about the Long-Term Course of Early Onset Bipolar Disorder? A Review of the Current Evidence

Tolerability, Safety, and Effectiveness of Two Years of Treatment with Lurasidone in Children and Adolescents with Bipolar Depression

Manische Episode und bipolare affektive Störung

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