“…However, most of these rabbit models were induced experimentally, which limited their application in hereditary eye diseases. Due to the lack of a technology to generate targeted gene modifications in rabbits, for many years, genetically modified rabbit models for ocular disease studies were restricted to transgenic rabbits only (Kondo et al, 2009;Yokoyama et al, 2010;Hirota et al, 2012;Ueno et al, 2013Ueno et al, , 2019Asakawa et al, 2015Asakawa et al, , 2016Nagai et al, 2016;Nakagami et al, 2016;Kominami et al, 2017Kominami et al, , 2019Okado et al, 2017;Roy et al, 2019).…”