2019
DOI: 10.1016/j.exer.2019.04.026
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Course of loss of photoreceptor function and progressive Müller cell gliosis in rhodopsin P347L transgenic rabbits

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Cited by 8 publications
(6 citation statements)
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“… 13 , 15 19 Historically, retinal degeneration has been studied in rhodopsin Pro347Leu transgenic rabbits, a model of RP. 20 31 Recently, the emerging gene editing technology in rabbits has greatly increased their value to biomedicine, motivating our efforts to develop rabbits that carrying the disease causing mutations found in human patients, as models to replicate human diseases more precisely. 32 34 In this study, we report the development of USH2A rabbits by CRISPR/Cas9.…”
Section: Introductionmentioning
confidence: 99%
“… 13 , 15 19 Historically, retinal degeneration has been studied in rhodopsin Pro347Leu transgenic rabbits, a model of RP. 20 31 Recently, the emerging gene editing technology in rabbits has greatly increased their value to biomedicine, motivating our efforts to develop rabbits that carrying the disease causing mutations found in human patients, as models to replicate human diseases more precisely. 32 34 In this study, we report the development of USH2A rabbits by CRISPR/Cas9.…”
Section: Introductionmentioning
confidence: 99%
“…Another factor that could affect the shape of the macula might be structural changes of the inner retina caused by retinal remodeling. 17 19 Although RP is initially a disorder of the photoreceptors, the inner retina has been reported to become progressively disorganized with a reprogramming of the retinal bipolar cells, alterations in protein signatures of the neurons, and intense gliosis of the Müller glial cells. 20 It is difficult to analyze the retinal remodeling from the OCT images; however, it is important to understand that the effects of changes of the inner retina on macular shape should be considered in RP eyes.…”
Section: Discussionmentioning
confidence: 99%
“…However, most of these rabbit models were induced experimentally, which limited their application in hereditary eye diseases. Due to the lack of a technology to generate targeted gene modifications in rabbits, for many years, genetically modified rabbit models for ocular disease studies were restricted to transgenic rabbits only (Kondo et al, 2009;Yokoyama et al, 2010;Hirota et al, 2012;Ueno et al, 2013Ueno et al, , 2019Asakawa et al, 2015Asakawa et al, , 2016Nagai et al, 2016;Nakagami et al, 2016;Kominami et al, 2017Kominami et al, , 2019Okado et al, 2017;Roy et al, 2019).…”
Section: Gene Edited Rabbits For Translational Studies Of Ocular Diseasesmentioning
confidence: 99%