Pulsed radiofrequency is an effective, safe, and nondestructive pain treatment technique that has been insufficiently reported in the treatment of supraorbital neuralgia. We report the successful use of pulsed radiofrequency to alleviate acute severe supraorbital neuralgia in a post-craniotomy patient. A 52-year-old female, who had acute severe supraorbital neuralgia after having received a right frontal craniotomy and with poor efficacy in response to medication and a nerve block, was subjected to ultrasound-guided pulsed radiofrequency treatment and experienced complete pain relief, as a result of which the patient stopped taking all analgesic drugs. The patient had follow-up visits for 1 year, during which she reported no pain. Furthermore, no side effects of nerve damage after pulsed radiofrequency were observed. Our results suggest that pulsed radiofrequency is a promising technique for the treatment of supraorbital neuralgia and that further studies of this technique should be conducted.