Course of Tourette Syndrome and Comorbidities in a Large Prospective Clinical Study

Groth, Camilla; Debes, Nanette Mol; Rask, Charlotte Ulrikka; Lange, Theis; Skov, Liselotte

doi:10.1016/j.jaac.2017.01.010

Cited by 160 publications

(120 citation statements)

References 25 publications

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“…Tics spontaneously fluctuate in number, distribution, frequency, and severity over time, exhibiting a characteristic waxing and waning course, usually with a peak in severity during early teenage years and improvement in adulthood. [18][19][20] Moreover, both psychological and environmental factors have been shown to modulate tic expression. Anxiety, stress, tiredness, and boredom are among commonly reported exacerbating factors, whereas mental and physical engagement in pleasant activities such as playing sports and music often ameliorate tics.…”

Section: Motor and Sensory Aspects Of Ticsmentioning

confidence: 99%

Gilles de la Tourette syndrome as a paradigmatic neuropsychiatric disorder

Cavanna

2018

CNS Spectr.

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Gilles de la Tourette syndrome is a chronic and complex tic disorder accompanied by specific behavioral problems in the majority of patients. With its multifaceted interplay between motion and emotion, this condition is a paradigmatic example of the science and art of clinical neuropsychiatry. This review article encompasses the clinical phenomenology of motor and vocal tics and associated sensory experiences (premonitory urges), as well as the behavioral spectrum of the most common comorbidities, including obsessive-compulsive disorder, attention-deficit and hyperactivity disorder, affective symptoms, and impulsivity. Knowledge of the contributions of both tics and behavioral problems to patients' health-related quality of life across the lifespan should assist treating clinicians in formulating a targeted management plan. Although the exact pathophysiology of Gilles de la Tourette syndrome remains elusive, research into therapeutic interventions has expanded the range of available interventions across multiple domains. A thorough understanding of the neurology and psychiatry of this condition is of key importance to meet the needs of this patient population, from the formulation of an accurate diagnosis to the implementation of effective treatment strategies.

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Section: Motor and Sensory Aspects Of Ticsmentioning

confidence: 99%

Gilles de la Tourette syndrome as a paradigmatic neuropsychiatric disorder

Cavanna

2018

CNS Spectr.

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“…Regarding natural course and history, the fate of non-tic symptoms in TS has remained less well explored. A large Danish study reported follow-up data 6 years after enrolling 314 children and teenagers with TS, assessing tics and comorbidities (mainly obsessive–compulsive disorder (OCD) and Attention-Deficit/Hyperactivity Disorder (ADHD); N=226 at follow-up) ( Groth et al , 2017 ). Most patients’ tics improved over time, but almost a quarter of those over age 16 still had severe tics, and only a sixth had no tics.…”

Section: Resultsmentioning

confidence: 99%

Tourette syndrome research highlights from 2017

2018

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This is the fourth yearly article in the Tourette Syndrome Research Highlights series, summarizing research from 2017 relevant to Tourette syndrome and other tic disorders. The authors briefly summarize reports they consider most important or interesting. The highlights from 2018 article is being drafted on the Authorea online authoring platform, and readers are encouraged to add references or give feedback on our selections using the comments feature on that page. After the calendar year ends, the article is submitted as the annual update for the Tics collection on F1000Research.

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“…However, other studies have shown that tics are still present in 85-90% of TS patients at followup, including in subjects who believe their tics have disappeared [27][28][29] . Furthermore, tics almost always wax and wane in severity while present.…”

Section: Outcomementioning

confidence: 92%

Transient tics aren't: Outcome of recent-onset tic disorder at one year

Kim¹,

Greene²,

Bihun³

et al. 2018

Preprint

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Motor and vocal tics are common in childhood. The received wisdom among clinicians is that for most children the tics are temporary, disappearing within a few months. However, that common clinical teaching is based largely on biased and incomplete data. The present study was designed to prospectively assess outcome of children with what the current nomenclature calls Provisional Tic Disorder. We identified 43 children with recent onset tics (mean 3.3 months since tic onset) and re-examined 39 of them on the 12-month anniversary of their first tic. Tic symptoms improved on a group level at the 12-month follow-up, and only two children had more than minimal impairment due to tics. Remarkably, however, tics were present in all children at follow-up, although in several cases tics were apparent only when the child was observed remotely by video. Our results suggest that remission of Provisional Tic Disorder is the exception rather than the rule. We also identified several clinical features present at the first examination that predict one-year outcome; these include baseline tic severity, subsyndromal autism spectrum symptoms, and the presence of an anxiety disorder.

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Course of Tourette Syndrome and Comorbidities in a Large Prospective Clinical Study

Cited by 160 publications

References 25 publications

Gilles de la Tourette syndrome as a paradigmatic neuropsychiatric disorder

Gilles de la Tourette syndrome as a paradigmatic neuropsychiatric disorder

Tourette syndrome research highlights from 2017

Transient tics aren't: Outcome of recent-onset tic disorder at one year

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