Course of Treatment of Chronic Bleeding and Anemia with Systemic Bevacizumab Treatment in Hereditary Hemorrhagic Telangiectasia: A Retrospective Cohort

Abstract

Hereditary hemorrhagic telangiectasia (HHT), also known as Osler-Weber-Rendu syndrome, is a common autosomal dominant disorder that causes abnormal angiogenesis. Its prevalence has been re-ported as 1/5,000 in North America. However, since the diagnosis is often missed and some patients may be asymptomatic, the actual prevalence of the disease is estimated to be higher. 1,2 In the pathogenesis of the