2024
DOI: 10.1002/cptc.202400022
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Covalent and Visible‐Light Photoswitchable Derivatives of the Potent Synthetic Opioid Isotonitazene and Other Nitazenes

Ranit Lahmy,
Harald Hübner,
Peter Gmeiner
et al.

Abstract: Isotonitazene belongs to a potent class of m‐opioid receptor (µOR) ligands, known as nitazenes. The lack of knowledge surrounding this agonist and others in its class has sparked thorough re‐investigations. To aid in these investigations, the purportedly covalent yet underexplored nitazene BIT was biochemically re‐evaluated in this work, along with a newly synthesized analogue, Iso‐BIT. Moreover, in the pursuit of understanding the mechanism, function, and interactions of µOR, this study involved developing ph… Show more

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