Covalent attachment of Mn-porphyrin onto doxorubicin-loaded poly(lactic acid) nanoparticles for potential magnetic resonance imaging and pH-sensitive drug delivery

Jing, Lijia; Liang, Xiaolong; Li, Xiaoda; Yang, Yuxin; Dai, Zhifei

doi:10.1016/j.actbio.2013.08.018

Cited by 55 publications

(40 citation statements)

References 41 publications

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“…Several researchers have reported pH-sensitive particles such as liposomes with the aim of detecting cancer tissues or other acidic pathologic areas by MRI. [7][8][9][10][11][12][13] However, pH sensitivity was the only feature in these tools for cancer targeting, besides the enhanced permeability and retention effect. 25 Other researchers have developed nanoparticles conjugated to biomolecules (eg, antibody or peptides) to target and image cancer.…”

Section: Discussionmentioning

confidence: 99%

“…These stimulus-sensitive agents can be detected when switching from one state to another after exposure to a metabolic or physiological event in a specific molecular target. A variety of smart CAs have been developed that become activated in response to changes in pH, [7][8][9][10][11][12][13] to the presence of metal ions [14][15][16] through enzymatic activation, 17 and to the presence of oxygenated hemoglobin 18 or radicals 19 or upon exposure to ultrasounds 20 or changes in temperature. 21,22 These smart CAs have proven to be excellent MRI tools for very specific targets in vitro and in vivo.…”

Section: Introductionmentioning

confidence: 99%

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Self-assembled polymeric nanoparticles as new, smart contrast agents for cancer early detection using magnetic resonance imaging

Mouffouk

Dornelle

Lopes

et al. 2014

IJN

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Early cancer detection is a major factor in the reduction of mortality and cancer management cost. Here we developed a smart and targeted micelle-based contrast agent for magnetic resonance imaging (MRI), able to turn on its imaging capability in the presence of acidic cancer tissues. This smart contrast agent consists of pH-sensitive polymeric micelles formed by self-assembly of a diblock copolymer (poly(ethyleneglycol- b -trimethylsilyl methacrylate)), loaded with a gadolinium hydrophobic complex ( t BuBipyGd) and exploits the acidic pH in cancer tissues. In vitro MRI experiments showed that t BuBipyGd-loaded micelles were pH-sensitive, as they turned on their imaging capability only in an acidic microenvironment. The micelle-targeting ability toward cancer cells was enhanced by conjugation with an antibody against the MUC1 protein. The ability of our antibody-decorated micelles to be switched on in acidic microenvironments and to target cancer cells expressing specific antigens, together with its high Gd(III) content and its small size (35–40 nm) reveals their potential use for early cancer detection by MRI.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Self-assembled polymeric nanoparticles as new, smart contrast agents for cancer early detection using magnetic resonance imaging

Mouffouk

Dornelle

Lopes

et al. 2014

IJN

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“…Jing et al 435 loaded DOX onto a polylactic acid polymeric NP and combined it with Mn–porphyrin to create a nano-carrier for imaging as well as therapeutic applications in HeLa cells. A DOX loaded magnetic coated polymeric NP could be useful for imaging and also showed high anticancer activity against prostate tumor cells at 40 °C and pH of 6.…”

Section: Dual and Multi-responsive Mnps In Ddss And The Role Of Gramentioning

confidence: 99%

Smart micro/nanoparticles in stimulus-responsive drug/gene delivery systems

et al. 2016

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New achievements in the realm of nanoscience and innovative techniques of nanomedicine have moved micro/nanoparticles (MNPs) to the point of becoming actually useful for practical applications in the near future. Various differences between the extracellular and intracellular environments of cancerous and normal cells and the particular characteristics of tumors such as physicochemical properties, neovasculature, elasticity, surface electrical charge, and pH have motivated the design and fabrication of inventive “smart” MNPs for stimulus-responsive controlled drug release. These novel MNPs can be tailored to be responsive to pH variations, redox potential, enzymatic activation, thermal gradients, magnetic fields, light, and ultrasound (US), or can even be responsive to dual or multi-combinations of different stimuli. This unparalleled capability has increased their importance as site-specific controlled drug delivery systems (DDSs) and has encouraged their rapid development in recent years. An in-depth understanding of the underlying mechanisms of these DDS approaches is expected to further contribute to this groundbreaking field of nanomedicine. Smart nanocarriers in the form of MNPs that can be triggered by internal or external stimulus are summarized and discussed in the present review, including pH-sensitive peptides and polymers, redox-responsive micelles and nanogels, thermo- or magnetic-responsive nanoparticles (NPs), mechanical- or electrical-responsive MNPs, light or ultrasound-sensitive particles, and multi-responsive MNPs including dual stimuli-sensitive nanosheets of graphene. This review highlights the recent advances of smart MNPs categorized according to their activation stimulus (physical, chemical, or biological) and looks forward to future pharmaceutical applications.

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“…Oleic acid-capped bNaYF 4 :Ce 3 + /Tb 3 + nanoparticles were encapsulated with a uniform mesoporous silica shell followed by surface modification with poly(ethylene glycol), which led to the formation of water-dispersible core-shell structured b-NaYF 4 :Ce 3 + /Tb 3 + @mSiO 2 -PEG nanospheres that exhibited a pH-sensitive drug release pattern for DOX·HCl, and the drug release was faster at lower pH values. Jing et al [107] reported the covalent attachment of Mn-porphyrin onto DOX-loaded poly(lactic acid) nanoparticles for potential magnetic resonance imaging and pHsensitive drug delivery.…”

Section: Inorganic/organic-composite Ph-responsive Drug-delivery Systemsmentioning

confidence: 99%

pH‐Responsive Drug‐Delivery Systems

Zhu

Chen

2014

Chemistry An Asian Journal

177

104

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In many biomedical applications, drugs need to be delivered in response to the pH value in the body. In fact, it is desirable if the drugs can be administered in a controlled manner that precisely matches physiological needs at targeted sites and at predetermined release rates for predefined periods of time. Different organs, tissues, and cellular compartments have different pH values, which makes the pH value a suitable stimulus for controlled drug release. pH-Responsive drug-delivery systems have attracted more and more interest as "smart" drug-delivery systems for overcoming the shortcomings of conventional drug formulations because they are able to deliver drugs in a controlled manner at a specific site and time, which results in high therapeutic efficacy. This focus review is not intended to offer a comprehensive review on the research devoted to pH-responsive drug-delivery systems; instead, it presents some recent progress obtained for pH-responsive drug-delivery systems and future perspectives. There are a large number of publications available on this topic, but only a selection of examples will be discussed.

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Covalent attachment of Mn-porphyrin onto doxorubicin-loaded poly(lactic acid) nanoparticles for potential magnetic resonance imaging and pH-sensitive drug delivery

Cited by 55 publications

References 41 publications

Self-assembled polymeric nanoparticles as new, smart contrast agents for cancer early detection using magnetic resonance imaging

Self-assembled polymeric nanoparticles as new, smart contrast agents for cancer early detection using magnetic resonance imaging

Smart micro/nanoparticles in stimulus-responsive drug/gene delivery systems

pH‐Responsive Drug‐Delivery Systems

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