Covalent molecular imprinting of bisphenol A using its diesters followed by the reductive cleavage with LiAlH4

On-Line Sample Pre-Treatment Procedures Applied to LC–MS

“…In particular, the analysis of phenolic compounds such as bisphenol A has generated some interest. 147 Ou 148 demonstrated that it was possible to add the MIP to a monolithic substrate by in situ polymerization using 4-vinylpyridine (4-VP) and ethylenedimethacrylate (EDMA) as functional monomer and cross-linker, respectively. Bisphenol A was used as the template molecules but the authors looked at six phenolic compounds in total.…”

Bisphenol A Analog-Imprinted Polymers Prepared by an Immobilized Template on a Modified Silica Microsphere Matrix

“…2) was investigated by measuring their retention on imprinted polymers with a mobile phase of chloroform/acetonitrile (9:1 (v/v)). Because previously reported BPA-imprinted polymers exhibited high affinities for BPA and its structural analogue compounds, [14][15][16] we employed this condition. The results are shown in Fig.…”

“…These results correlate with those from our previous studies. 15,16 The two hydroxyl groups of bisphenol appear to interact strongly with 4-VPy in the binding sites, whereas other compounds having only one hydroxyl group (5, 6) showed very weak binding affinity. This lower affinity may arise from the formation of only one hydrogen-bonding interaction in the binding site.…”

“…Due to such characteristics, many research groups reported BPA-imprinted polymers prepared using various templates. [11][12][13][14][15][16] We report herein a BPA binding imprinted polymer that has been prepared by immobilization of the template, 4,4′-bis(4-hydroxyphenyl)valeric acid, to a silica matrix. This yielded imprinted polymers of uniform size and shape with structurally controlled binding sites.…”

N‐isopropylacrylamide as a functional monomer for noncovalent molecular imprinting

“…Molecular recognition materials that can selectively absorb BPA are required. BPA‐imprinted polymers (BIPs) have previously been prepared both noncovalently (Haginaka and Sanbe, ; Kanekiyo et al , ; San Vicente et al , ; Watabe et al , ; Kawaguchi et al , ; Sanbe et al , ; Yang et al , ; Watabe et al , ) and semi‐covalently (Ikegami et al, ). In this study, the recognition properties of a BIP prepared using NIPAM were compared with MIPs prepared using conventional functional monomers MAA, AAm and 4‐VPy.…”