Covalently assembled dopamine nanoparticle as an intrinsic photosensitizer and pH-responsive nanocarrier for potential application in anticancer therapy

Li, Hong; Zhao, Yuanyuan; Jia, Yi; Qu, Chengtun; Li, Junbai

doi:10.1039/c9cc08294h

Cited by 86 publications

(35 citation statements)

References 25 publications

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“…It is worth noting that targeting an acidic tumor microenvironment is quite a versatile approach for anticancer therapy and has been successfully employed not only for VCC but also for other carriers, e.g. polymeric nanoparticles; 105 this supports the potency of this strategy. The pH sensitivity of VCC crystals limits their oral administration (at least if the crystals are not functionalized) due to the swift VCC dissolution and the loss of the payload in the stomach (pH B 1.5-3.5).…”

Section: Caco 3 and Its Polymorphsmentioning

confidence: 64%

Naturally derived nano- and micro-drug delivery vehicles: halloysite, vaterite and nanocellulose

et al. 2020

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Section: Caco 3 and Its Polymorphsmentioning

confidence: 64%

Naturally derived nano- and micro-drug delivery vehicles: halloysite, vaterite and nanocellulose

et al. 2020

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“…Min et al reported another approach for PS loading using UCN@mSiO 2 for RB encapsulation in its porous shell layer. [64,86] At 980 nm irradiation, the RB-loaded UCN core emitted luminescence at 540 nm, which was effectively transferred for RB [ 289] MSN (Alkylthioethene) ZnPc (525) Naphthalene dye [ 159] Liposome Tetraphenylchlorin Paclitaxel (Thioether) [ 290] Crosslinked polymer Poly(dopamine) (635) Bortezomib (Catechol-boronate) [ 291] Disassembly Liposome (Dehydrocholesterol) Tetraphenylporphyrin (420) Dehydrocholesterol endoperoxide [ 292] Polymer micelle (Alkoxyanthracene) Eosin Y (525) Mitoxantrone [ 117] Polymer micelle (Alkoxyanthracene) Anthracene (365) DOX [32] Polymer micelle (Thioether) Ce6 (660) DOX [ 115] Polymer micelle (Propylene sulfide) Chlorin e6 (670) DOX [ 116] Polymer micelle PPIX (635) SN38 (Thioether) [ 293] Polymer micelle Porphyrin (400) Se (Diselenide) [ 294] Polymer micelle Poly(fluorine-benzothiadiazole) (Vis) Vancomycin, PMB [ 303] RGD-targeted polymer micelle Indocyanine (660) Camptothecin [ 295] UCN@PEI Curcumin (432; 980) Curcumin [ 308] UCN@mSiO 2 UCN (980); RB (540) RB [64,86] UCN yolk-shell UCN (980); RB, hematoporphyrin (540) RB, hematoporphyrin [64] UCN@Au/TiO 2 UCN (980); TiO 2 (NIR) Ampicillin [ 310] UCN@poly(vinylpyrrolidone) UCN (980); ZnPc ZnPc [ 301] UCN@chitosan UCN (980); ZnPc ZnPc [ 309] activation for ROS production and disassembly. This accounted for a potent antibacterial activity against MRSA and extended spectrum beta-lactamase-producing E. coli.…”

Section: Ros Disassembly By Upconversion Luminescencementioning

confidence: 99%

Photoactivation Strategies for Therapeutic Release in Nanodelivery Systems

Choi

2020

Advanced Therapeutics

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Control of therapeutic release constitutes one of most critical aspects considered in the design of nanoscale delivery systems. There are a variety of cellular factors and external stimuli employed for release control. Of these, use of light offers various photoactivation mechanisms that enable to effectively engage in therapeutic release. It also allows a higher degree of spatial and temporal control. Over recent decades, the application of photoactivation strategies has seen remarkable growth and made a significant impact on rapid advances in the field of drug delivery. This Review aims to summarize the fundamental concepts and practical applications demonstrated recently in numerous therapeutic areas from cancers to infectious diseases. Its scope is defined by a focus on those photoactivation strategies that occur via either linker cleavage, nanocontainer gating, or disassembly. Each of these is discussed with specific examples and underlying mechanisms that comprise linker photolysis, photoisomerization, photothermal heating, or photodynamic reactions with reactive oxygen species. In summary, this Review provides an inclusive summary of new developments and insights obtained from recent progress in photoactivation strategies and their applications in therapeutic nanodelivery.

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“…[ 6–9 ] PDA has been applied in the biomedical field that for drug delivery, bioimaging, and tissue engineering biosensing applications. [ 10–12 ] Because of its specific structure, PDA is capable of loading antitumor drugs (such as doxorubicin (DOX)) via π–π stacking or hydrogen bonding interactions, with loading rates as high as 91%. Surprisingly, in addition to its strong ability to adsorb drugs, PDA is effective in releasing drugs by internal stimulation (hydrogen peroxide) or from an external stimulus (near‐infrared (NIR) irradiation), reducing the toxic effects of chemotherapeutic drugs.…”

Section: Introductionmentioning

confidence: 99%

Mussel‐Inspired Polydopamine: The Bridge for Targeting Drug Delivery System and Synergistic Cancer Treatment

Wang

Tang

Zhang

et al. 2020

Macromolecular Bioscience

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PDA has been applied in the biomedical field that for drug delivery, bioimaging, and tissue engineering biosensing applications. [10-12] Because of its specific structure, PDA is capable of loading antitumor drugs (such as doxorubicin (DOX)) via π-π stacking or hydrogen bonding interactions, with loading rates as high as 91%. Surprisingly, in addition to its strong ability to adsorb drugs, PDA is effective in releasing drugs by internal stimulation (hydrogen peroxide) or from an external stimulus (nearinfrared (NIR) irradiation), reducing the toxic effects of chemotherapeutic drugs. [13-15] Moreover, by exhibiting 40% light-to-heat conversion efficiency, PDA can act as a photothermal agent, able to produce sufficient heat to ablate cancer cells when irradiated with 808 nm NIR light. Compared with other photothermal materials, including carbon or copper-based nanomaterials and gold nanoparticles, the photothermal conversion effect of PDA is greater with better biocompatibility. [16-20] It has been reported that monotherapy has multiple limitations due to its heterogeneity and the drug resistance of tumors, with synergistic therapies that are more effective for cancer treatment. [21] Because of the large number of catechol and amine groups, PDA displays superior adhesion, endowing PDA films with the ability to adhere to a variety of material surfaces, such as gold nanoparticles, iron oxide, silica, and polylactic-co-glycolic acid (PLGA). Thus, PDA has been utilized to functionalize almost every form of nanomaterial by dopamine polymerization. More importantly, a layer of PDA provides nanomaterials with highly desirable properties, including the ability to be loaded with drugs allowing their controlled-release, excellent photothermal conversion efficiency and biocompatibility, and so facilitating the creation of multifunctional drug delivery systems for combined treatment by combining photothermal therapy (PTT) or chemotherapy with other therapies. [22-25] Additionally, the catechol and amino groups on PDA provide a bridge for subsequent modification. For example, PDA can act as a link to introduce tumor-targeting ligands using its amine and thiol groups via a Michael addition or Schiff reaction, allowing nanoparticles to become enriched at the tumor site. [26-28] Using these properties of PDA, researchers have developed diverse forms of PDA-based multifunctional platforms for synergistic cancer therapies. Wang et al. [29] reviewed Polydopamine (PDA), a mussel-inspired molecule, has been recognized as attractive in cancer therapy due to a number of inherent advantages, such as good biocompatibility, outstanding drug-loading capacity, degradability, superior photothermal conversion efficiency, and low tissue toxicity. Furthermore, due to its strong adhesive property, PDA is able to functionalize various nanomaterials, facilitating the construction of a PDA-based multifunctional platform for targeted or synergistic therapy. Herein, recent PDA research, including targeted drug delivery, single-mode therapy, and diverse...

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Covalently assembled dopamine nanoparticle as an intrinsic photosensitizer and pH-responsive nanocarrier for potential application in anticancer therapy

Abstract: A covalently assembled dopamine nanoparticle is constructed to serve as an intrinsic photosensitizer and pH-responsive drug nanocarrier for combined PDT and chemotherapy.

Cited by 86 publications

References 25 publications

Naturally derived nano- and micro-drug delivery vehicles: halloysite, vaterite and nanocellulose

Naturally derived nano- and micro-drug delivery vehicles: halloysite, vaterite and nanocellulose

Photoactivation Strategies for Therapeutic Release in Nanodelivery Systems

Mussel‐Inspired Polydopamine: The Bridge for Targeting Drug Delivery System and Synergistic Cancer Treatment

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