Covalently stabilized trimethyl chitosan-hyaluronic acid nanoparticles for nasal and intradermal vaccination

Verheul, Rolf J.; Slütter, Bram; Bal, Suzanne M.; Bouwstra, Joke A.; Jiskoot, Wim; Hennink, Wim E.

doi:10.1016/j.jconrel.2011.07.014

Cited by 96 publications

(61 citation statements)

References 44 publications

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“…5B-C). Verheul et al [37] showed that disulfidecrosslinked chitosan-hyaluronic acid nanoparticles significantly increased OVA-specific IgG1 production without affecting IgG2a levels. In the present study, all three IgG isotypes were robustly increased by the bioreducible AP-SS nanogels, suggesting the modulation of intracellular antigen processing could be an effectively strategy to enhance vaccine-induced humoral responses.…”

Section: The Effect Of Alginate-pei Nanogels On Vaccine-induced Antibmentioning

confidence: 99%

Bioreducible alginate-poly(ethylenimine) nanogels as an antigen-delivery system robustly enhance vaccine-elicited humoral and cellular immune responses

Luo

Liu

et al. 2013

Journal of Controlled Release

140

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Section: The Effect Of Alginate-pei Nanogels On Vaccine-induced Antibmentioning

confidence: 99%

Bioreducible alginate-poly(ethylenimine) nanogels as an antigen-delivery system robustly enhance vaccine-elicited humoral and cellular immune responses

Luo

Liu

et al. 2013

Journal of Controlled Release

140

View full text Add to dashboard Cite

“…Similarly, trimethyl and mono-N-carboxymethyl chitosan-based nanoparticles encapsulated with tetanus toxoid antigen enhanced both mucosal and systemic immune responses in response to vaccination via the nasal route [65]. To prove this concept, Verheul et al [66] fabricated trimethylchitosan particles with hyaluronic acid and found improved adjuvant potential compared with trimethylchitosan particles alone for nasal and intradermal vaccinations.…”

Section: Natural Polymersmentioning

confidence: 99%

Applications of polymeric adjuvants in studying autoimmune responses and vaccination against infectious diseases

Shakya

Nandakumar

2013

J. R. Soc. Interface.

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Polymers as an adjuvant are capable of enhancing the vaccine potential against various infectious diseases and also are being used to study the actual autoimmune responses using self-antigen(s) without involving any major immune deviation. Several natural polysaccharides and their derivatives originating from microbes and plants have been tested for their adjuvant potential. Similarly, numerous synthetic polymers including polyelectrolytes, polyesters, polyanhydrides, non-ionic block copolymers and external stimuli responsive polymers have demonstrated adjuvant capacity using different antigens. Adjuvant potential of these polymers mainly depends on their solubility, molecular weight, degree of branching and the conformation of polymeric backbone. These polymers have the ability not only to activate humoral but also cellular immune responses in the host. The depot effect, which involves slow release of antigen over a long duration of time, using different forms (particulate, solution and gel) of polymers, and enhances the co-stimulatory signals for optimal immune activation, is the underlying principle of their adjuvant properties. Possibly, polymers may also interact and activate various toll-like receptors and inflammasomes, thus involving several innate immune system players in the ensuing immune response. Biocompatibility, biodegradability, easy production and purification, and non-toxic properties of most of the polymers make them attractive candidates for substituting conventional adjuvants that have undesirable effects in the host.

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“…The study further showed stability of the protein following freeze-drying and showed acceptable toxicity via MTT assay. Sodium alginate Carvedilol Nasal insufflator 2011 [160] Venlafaxine HCl Nasal gel 2012 [161] Pectin Ondansetron HCl Nasal powder 2012 [162] Tacrine HCl Microparticle 2013 [163] Hyaluronic acid Ovalbumin Nanoparticles 2011 [164] …”

Section: Polysaccharide-based Nasal Delivery Systemsmentioning

confidence: 99%

Polysaccharide Based Formulations for Mucosal Drug Delivery: A Review

Boateng

Okeke²,

Khan³

2015

CPD

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There has been increased interest in novel drug delivery systems to be administered via mucosal routes as an alternative to the currently used traditional routes such as parenteral (injections) and oral routes of administration. This is due to the several advantages they offer including avoiding first pass metabolism in the liver for oral administration and local activity which avoids the need for high systemic doses. To achieve the foregoing objectives, bioadhesive vehicles are required that ensure prolonged residence time to achieve systemic bioavailability via substantial drug absorption or significant drug concentration for local action.The drug delivery system is also required to be non-deleterious to the site of application and be well tolerated by vulnerable groups such as paediatric and geriatric patients. These essential characteristics are mainly satisfied by naturally occurring polymers, including polysaccharide based polymers which have the advantage of biocompatibility, biodegradability and therefore safety. This review discusses various bioadhesive polymers of polysaccharide origin formulated into a variety of dosage forms for drug delivery via the body's mucosal (moist) surfaces including ocular, oral (buccal and sublingual), nasal, gastrointestinal and vaginal mucosa, as well as moist wound sites. The anatomy and / or physiology of each site, coupled with the unique challenges each poses, the strategies employed for ensuring therapeutic efficacy, as well as the current state of the art will also be covered.

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Covalently stabilized trimethyl chitosan-hyaluronic acid nanoparticles for nasal and intradermal vaccination

Cited by 96 publications

References 44 publications

Bioreducible alginate-poly(ethylenimine) nanogels as an antigen-delivery system robustly enhance vaccine-elicited humoral and cellular immune responses

Bioreducible alginate-poly(ethylenimine) nanogels as an antigen-delivery system robustly enhance vaccine-elicited humoral and cellular immune responses

Applications of polymeric adjuvants in studying autoimmune responses and vaccination against infectious diseases

Polysaccharide Based Formulations for Mucosal Drug Delivery: A Review

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