Multi-species cover crop mixtures have been increasing in popularity. It has been hypothesized these mixtures produce more biomass, suppress more weeds, scavenge more N, conserve more soil water, stimulate more soil biology, promote higher yields of subsequent crops, and have higher production stability than the best of their monoculture counterparts. This systematic review synthesizes a growing body of cover crop mixture research to assess, for these metrics, whether cover crop mixtures can perform better than their constituent species when planted alone. Searching three databases, we identified 27 studies which compared cover crop mixtures (containing at least three species) to all their constituent species. The studies contained 119 sampled cover crop plantings that met our eligibility criteria. From these, we extracted 243 full comparisons of the bestperforming mixture and best-performing monoculture for the selected metrics. In 88% of these comparisons, the monoculture and mixture performed comparably. In 10% of the comparisons, the monoculture did better, and in 2% of comparisons the mixture performed better. Overall, there are few published studies documenting the superiority of cover crop mixtures over monocultures for our selected metrics. Abbreviations: CC, cover crop; CV, coefficient of variation; LER, land equivalent ratio; RYT, relative yield total. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.