Cover Feature: A Nazarov‐Ene Tandem Reaction for the Stereoselective Construction of Spiro Compounds (Chem. Eur. J. 36/2021)

Abstract

A tandem Nazarov/ene reaction in trienones was found to be initiated by tris(pentafluorophenyl)borane (TPPB) and resulted in spiro compounds as single diastereoisomers. The reaction was applied to a set of substrates with different chain lengths and functionalities, and investigations on the mechanism were conducted. This novel diastereoselective reaction extends the application of interrupted Nazarov cyclizations as tools for the synthesis of natural products. More information can be found in the Communication by M. Kalesse et al. (DOI: 10.1002/chem.202101041).