Cover Feature: Ability of Azathiacyclen Ligands To Stop Cu(Aβ)‐Induced Production of Reactive Oxygen Species: [3N1S] Is the Right Donor Set (Chem. Eur. J. 14/2023)

Abstract

Cu bound to Aβ (heads of the meteorites) produces reactive oxygen species (tails) that attack the brain. In the presence of the azamacrocyclic ligand 3N1S (the green belt), the Cu ions are removed by the ligand (the head of the meteorite is broken) and the ROS production is abolished (the tail disappears). Hence, the brain is safe behind its shield. In absence of 3N1S, the ROS produced by Cu(Aβ) attack the brain, which is “destroyed”. More information can be found in the Research Article by C. Esmieu, C. Hureau, and co‐workers (DOI: 10.1002/chem.202203667).

Reduced Schiff-base derivatives to stop reactive oxygen species production by the Cu(Aβ) species: a structure–activity relationship

“…More specifically, such a method is more suited to screen between various ligands than the individual determination of Cu(L) and Zn(L) formation that would also release the selectivity of the L (see introduction). In experiments B, additional kinetic parameters are involved (Scheme 2A) [40][41][42][43]. Indeed, during Asc consumption, Cu oscillates between the +I and +II redox states.…”