Cover Feature: Characterization of a Tryptophan 6‐Halogenase from Streptomyces albus and Its Regioselectivity Determinants (ChemBioChem 10/2020)

Abstract

Changing nature: Tryptophan halogenases, which play an important role in the biosynthesis of halogenated indole alkaloids, are found in diverse organisms and catalyze regiospecific halogenation. A tryptophan 6‐halogenase from S. albus is identified, and key residues that determine the regioselectivity difference between tryptophan 6‐ and 5‐halogenases are investigated. More information can be found in the full paper by B.‐G. Kim et al. on page 1446 in Issue 10, 2020 (DOI: 10.1002/cbic.201900723).