Cover Feature: Highly Selective Hydrogenative Conversion of Nitriles into Tertiary, Secondary, and Primary Amines under Flow Reaction Conditions (ChemSusChem 2/2022)

Continuous-Flow Enantioselective Hydrogenative Enyne Cyclization with Chiral Heterogeneous Rh Catalysts

“…On the other hand, both substrates in solutions and gaseous molecules can directly and efficiently interact with heterogeneous catalysts under flow conditions; therefore reactions can be performed under mild conditions, and significant rate acceleration was observed in some cases by overcoming the problem of mass transfer . By making use of this unique nature of flow reactions, continuous-flow hydrogenations of various kinds of functional groups have been developed until now. − Reported examples are, however, limited to only simple functional group interconversions and (hetero)­arene hydrogenations, and continuous-flow enantioselective hydrogenative C−C bond forming reactions, which can construct chiral molecular scaffolds, remain unexplored.…”