2021
DOI: 10.1002/ejoc.202100579
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Cover Feature: The Ugly Duckling Metamorphosis: The Ammonia/Formaldehyde Couple Made Possible in Ugi Reactions. (Eur. J. Org. Chem. 20/2021)

Abstract: The Cover Feature shows a combination that could be called the ugly duckling of the Ugi 4‐component reactions, which involves the concomitant use of the ammonia/formaldehyde pair. There was not a single methodology so far to successfully achieve this goal. The metamorphosis could finally happen with the intermediacy of hexamethylenetetramine (HMTA), which allows the in situ generation of both ammonia and formaldehyde for the Ugi reactions with carboxylic acids and isocyanides, yielding a variety of acylaminoac… Show more

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