Cover Image

Abstract

The cover image, by Enrica Vescarelli et al., is based on the In Vitro Research Autophagy activation is required for myofibroblast differentiation during healing of oral mucosa, DOI: .

Autophagy, tissue repair, and fibrosis: a delicate balance

“…In this setting, oral mucosa fibroblasts displayed higher a-SMA and collagen deposition after surgical incision along with autophagy activation. In contrast, gingiva fibroblasts lacking the capacity to mount an autophagic response failed to differentiate into myofibroblasts [16]. These studies highlight the need for fine control of autophagy in specific tissue fibroblasts to allow normal tissue repair without fibrosis and scar formation.…”