Cover Picture: Macromol. Biosci. 6/2006

Choi, Hak; Ooya, Tooru; Yui, Nobuhiko

doi:10.1002/mabi.200690010

Cited by 15 publications

(19 citation statements)

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“…The often low yields of stoppering are improvable by the use of organic solvents, like N , N -dimethylformamide (DMF), [ 31 ] but these solvents also foster dissociation of the threaded rings. There are only a few studies on the one-pot synthesis of CD polyrotaxanes in water [ 29,[33][34][35][36][37] or in organic solvents. [ 38 ] These approaches are based on threading CDs onto an existing non or moderately hydrophobic polymer chain followed by end-capping, mostly with urethane or click chemistry by heterogenous reactions resulting in water insoluble polyrotaxanes.…”

mentioning

confidence: 99%

One Pot Synthesis of a Polyisoprene Polyrotaxane and Conversion to a Slide‐Ring Gel

Kali

Eisenbarth

Wenz

2015

Macromol. Rapid Commun.

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Synthesis of a cyclodextrin (CD) polyrotaxane is achieved for the first time by simultaneous free radical polymerization of isoprene, threading by CD, and stoppering by copolymerization of styrene. This reaction is performed in an eco-friendly manner in an aqueous medium similar to classical emulsion polymerization. Threaded CD rings of the polyrotaxane are cross-linked by hexamethylene diisocyanate, leading to highly elastic slide-ring gels.

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mentioning

confidence: 99%

One Pot Synthesis of a Polyisoprene Polyrotaxane and Conversion to a Slide‐Ring Gel

Kali

Eisenbarth

Wenz

2015

Macromol. Rapid Commun.

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“…Nanocarriers produced from PEG-PEI copolymers also have a longer circulation time since PEG conjugation prevents opsonization. [93][94][95] PEG-PEI (800 kDa) polyplexes were manufactured through grafting of transferrin to PEG and this modification resulted in a five-fold increase in transfection efficiency and decreased toxicity. 96 …”

Section: Polyethyleniminementioning

confidence: 99%

Cationic Polymer Nanoparticles for Drug and Gene Delivery

Bilensoy

Işık

Varan

2014

Cationic Polymers in Regenerative Medicine

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Conventional therapies of several diseases, in particular cancer therapy, have been insufficient clinically for effective and safe treatment of these important diseases. The major cause of side effects is insufficient uptake and non-selective delivery of therapeutic molecules. In order to overcome this problem, colloidal, nano-sized carrier systems have been developed for gene and drug delivery. These novel delivery systems have a wide range of modification capabilities, such as controllable particle size and surface charge or grafting of different molecules for active or passive targeting to cells. A variety of modification or formulation approaches ensure the efficacy, equality and safety of the system. In this context, cationic nano-sized drug delivery systems have a net positive surface charge, suggesting strong cellular interactions with negatively charged biological membranes. This electrostatic interaction between cationic nanoparticles and cell membranes brings with it enhanced uptake of nanoparticles by cells. Another important advantage of cationic nanocarriers is that they are able to condense DNA, siRNA, nucleotides, peptides and proteins to form polyplexes that are able to deliver their load intracellularly, resulting in increased transfection efficiency. In this chapter the surface properties, cellular interaction and uptake mechanism of nano-sized drug carrier systems and the innovations in treatment are described using examples from the literature. In addition, various cationic polymers commonly used in drug and gene delivery and their characteristics are summarized. Positively charged nanocarrier systems emerge as a promising option for effective drug or gene therapy and extensive research is being carried out in this field worldwide.

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“…The resulting polyrotaxanes survived dissolution in organic solvents and were further modified at the threaded CD rings (e.g., by intramolecular crosslinking with epichlorohydrine leading to molecular tubes63 or hydroxypropylation giving rise to water‐soluble polyrotaxanes) 64. Meanwhile, a great variety of CD polyrotaxanes comprised from polymers such as polyethers,65, 66 polyethyleneimine,67, 68 polysiloxanes,69 polypyrrole,70 poly(phenylene‐vinylene)s,71 α‐CD rings,66 β‐CD rings,65, 69, 72 and γ‐CD73, 74 rings were synthesized.…”

Section: Pseudopolyrotaxanes– Polyrotaxanesmentioning

confidence: 99%

Cyclodextrin polyrotaxanes assembled from a molecular construction kit in aqueous solution

Wenz

2009

J. Polym. Sci. A Polym. Chem.

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ABSTRACT:We describe a molecular construction kit in which amphiphilic polymers and functionalized cyclodextrins are arranged into sophisticated molecular architectures in aqueous solution without the need to perform chemical reactions. Therefore, these systems are highly biocompatible and show programmable lifetimes. The kinetic stabilities of our polyrotaxane structures are tunable using sterically demanding groups that hinder dissociation. These cyclodextrinbased polymer systems are applicable in principle for the detection of analytes at the level of single molecules. These systems may also serve well in targeted drug delivery and gene transfection.

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Cover Picture: Macromol. Biosci. 6/2006

Cited by 15 publications

References 0 publications

One Pot Synthesis of a Polyisoprene Polyrotaxane and Conversion to a Slide‐Ring Gel

One Pot Synthesis of a Polyisoprene Polyrotaxane and Conversion to a Slide‐Ring Gel

Cationic Polymer Nanoparticles for Drug and Gene Delivery

Cyclodextrin polyrotaxanes assembled from a molecular construction kit in aqueous solution

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