2020
DOI: 10.1186/s12936-020-03155-2
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Coverage and effectiveness of intermittent preventive treatment in pregnancy with sulfadoxine–pyrimethamine (IPTp-SP) on adverse pregnancy outcomes in the Mount Cameroon area, South West Cameroon

Abstract: Background: Growing concerns about the waning efficacy of IPTp-SP warrants continuous monitoring and evaluation. This study determined coverage of IPTp-SP and compared the effectiveness of the 3-dose to 2-dose regimen on placental malaria (PM) infection and low birth weight (LBW) in the Mount Cameroon area. Methods: Consenting pregnant women were enrolled consecutively through a cross-sectional survey at delivery at four antenatal clinics, two each from semi-rural and semi-urban settings from November 2016 to … Show more

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Cited by 25 publications
(29 citation statements)
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“…In South West Cameroon, ≥ 3 doses were associated with lower odds of LBW compared to ≤ 1 dose, but unlike our study, no difference was detected between ≥ 3 doses and 2 doses [45]. In Southeast Tanzania, higher birth weight was seen with ≥ 3 doses compared to two doses, as well as lower risk of LBW [46].…”
Section: Discussioncontrasting
confidence: 71%
“…In South West Cameroon, ≥ 3 doses were associated with lower odds of LBW compared to ≤ 1 dose, but unlike our study, no difference was detected between ≥ 3 doses and 2 doses [45]. In Southeast Tanzania, higher birth weight was seen with ≥ 3 doses compared to two doses, as well as lower risk of LBW [46].…”
Section: Discussioncontrasting
confidence: 71%
“…This high prevalence of quadruple mutants suggests high risks of SP treatment failure in IPTp and SMC. Mutations Pfdhps K540E and A581G are key indicators for the quintuple and sextuple mutants associated to SP failure [ 40 , 41 ]. In 2015, the quintuple mutant that includes the Pfdhps 540E mutation was found in two samples from Yaounde in women who had taken SP in IPTp [ 9 ].…”
Section: Discussionmentioning
confidence: 99%
“…SNPs in the dihydrofolate reductase ( dhfr ) [ 30 , 36 , 37 ] and dihydropteroate synthase ( dhps ) genes [ 38 ] are associated with SP resistance. Successive accumulation of mutations in both Pdhfr and Pdhps genes confers high levels of SP resistance and clinical treatment failure in several epidemiological settings [ 39 , 40 ].…”
Section: Introductionmentioning
confidence: 99%
“…Malaria during pregnancy is a major public health problem that can lead to unfavourable pregnancy and birth outcomes such as abortion, preterm delivery, stillbirth, maternal anaemia and low birth weight (LBW). [1][2][3] In 2018, an estimated 11 million of 38 million (29%) pregnancies were exposed to malaria in sub-Saharan Africa with 35% of pregnancies in West Africa exposed to malaria during the same period. 4…”
Section: Introductionmentioning
confidence: 99%