Coverage and outcomes of antenatal tests for infections: a population based survey in the Province of Trento, Italy

Dalmartello, Michela; Parazzini, Fabio; Pedron, Mariangela; Pertile, Riccardo; Collini, Lucia; Vecchia, Carlo La; Piffer, Silvano

doi:10.1080/14767058.2018.1424822

Cited by 16 publications

(11 citation statements)

References 26 publications

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“…Prevalence in pregnant women is also consistent with this trend toward a decrease observed in Italy. Epidemiological studies conducted on T. gondii seroprevalence in pregnant women between the 1980's and 1990's revealed rates ranging from 40.4% in Naples to 48.7% in the area of Parma [3,4,30], whereas more recent studies have found rates of T. gondii prevalence in pregnant women between 21.5% and 27.5% [5,7,8,26]. Pregnant women in this study showed a further decrease, with an overall prevalence of 13.8%.…”

Section: Discussioncontrasting

confidence: 52%

Toxoplasma gondii in women of childbearing age and during pregnancy: seroprevalence study in Central and Southern Italy from 2013 to 2017

et al. 2020

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Toxoplasmosis is a worldwide health problem. Infection in pregnant women can result in severe fetal morbidity or in subclinical neonatal infection; most subclinical cases develop ocular and neurological sequelae. The purpose of this serological study was to assess the prevalence of Toxoplasma gondii in two populations of women of childbearing age in Siena (Tuscany, Central Italy) and Bari (Apulia, Southern Italy) between 2013 and 2017 and in a group of pregnant women in Bari in 2016–2017. Serum samples were tested for the presence of specific anti-Toxoplasma gondii IgG antibodies by a commercially available ELISA test. The percentage of seropositive subjects in Bari was significantly higher than in Siena (22.4% vs. 12.4%) and an age-related trend was observed. A low prevalence of T. gondii infection (13.8%) was observed among the pregnant women tested. In addition to showing a significant difference between Central and Southern Italy, this study provides updated data on T. gondii seroprevalence in women during childbearing age and pregnancy. The results confirm a trend toward a decrease, especially in younger people and pregnant women.

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Section: Discussioncontrasting

confidence: 52%

Toxoplasma gondii in women of childbearing age and during pregnancy: seroprevalence study in Central and Southern Italy from 2013 to 2017

et al. 2020

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“…Given the sensitivity of the data, access to the SIO must also take place in a manner aimed at ensuring the maximum possible confidentiality. The coverage of the GBS testing is, in the period under study, always greater than 90%, a value consistent with what was reported in our previous overall study and, as regards specifically the GBS, higher than that reported by a previous national survey by the National Institute of Health and other regional studies [3,5,24,25]. Coverage of GBS testing is higher in term births and in spoke maternity units, as reported by a previous Italian work [5].…”

Section: N Discussionsupporting

confidence: 90%

“…This allows an assessment by area rather than by centers, similarly to what has already been reported, for the Italian level, in the Emilia-Romagna region. An overall report on the surveillance of infections in pregnancy through the BAC in the province of Trento, for the period 2007-2014, was provided by our previous study [24]. However, this study represents our first in-depth evaluation of GBS infection in pregnancy.…”

Section: N Discussionmentioning

confidence: 99%

Screening of group B Streptococcus infection in pregnancy and neonatal outcomes in the province of Trento, Italy

Piffer¹,

Rizzello²,

Pedron³

et al. 2022

Infez Med

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cases appears uneven among the subgroups of pregnant women considered, even if the differences are not statistically significant. In the 2019 birth cohort, newborns to GBS-positive mothers had an excess of stillbirths, of those born with Apgar at 5 minutes <7 and hospitalized at birth. However, these excesses were not statistically significant. Intravenous Antibiotic Prophylaxis (IAP) was performed in 86.8% of births from GBS positive mothers who had an indication for IAP. IAP was inadequate in 7.4% of the GBS positive mothers. Postnatal evaluation of 783 live births to GBS positive mothers identified 3 cases of early neonatal GBS infection. The incidence of neonatal GBS infection over the whole series of live births is 0.71/1,000 (95% CI 0.56-0.86), 0.68/1000 (CI 95% 0.55-0.79) in Italians and 1.07/1000 (95% CI 0.45-1.65) in foreigners. Data collection on infections in pregnancy through BAC allows area-based assessment. The quality of the data recorded in the BAC can be considered satisfactory but it was necessary to access to other information sources. The local availability of various information sources should allow periodic audits and closer monitoring of neonatal GBS infection.

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“…Consistent with the two studies mentioned above, several authors claim that there is a decreasing trend in T. gondii infection among pregnant women (38). Epidemiological studies conducted on T. gondii seroprevalence in pregnant women before the 2000's revealed rates ranging from 40.4% to 48.7% in two areas of Italy, whereas some recent studies have found rates of T. gondii prevalence in pregnant women between 21.5 and 27.5% (39)(40)(41)(42).…”

Section: Discussionmentioning

confidence: 55%

Research on demographic, clinical and paraclinical aspects in pregnant women infected with Toxoplasma gondii

et al. 2021

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Toxoplasmosis is a zoonotic disease caused by the Toxoplasma gondii protozoan parasite. The aim of this study was to determine the frequency of acute toxoplasmosis or its presence in the medical history of 240 pregnant women, depending on age and geographical background. The second purpose was to analyze several medical aspects (clinical and paraclinical) in pregnant women with acute toxoplasmosis. The study identified several serological changes including positive toxoplasma IgM, IgG, and IgA antibodies. The chemiluminescence immunoassay (CLIA) method was used to detect T. gondii-specific IgM and IgG antibodies and the enzyme immunoassay (EIA) method to detect T. gondii-specific IgA antibodies. Of the 96 pregnant women (40%) infected with T. gondii, approximately 1/3 had acquired acute infection and 2/3 had a history of prior acute infection (P<0.0001). No statistically significant differences according to age groups (P= 0.9384) were found in terms of serological profile. The number of patients with negative serology was significantly higher in urban areas than in rural areas (P<0.0001). The highest incidence among the pregnant women with acute toxoplasmosis with a single chain of ganglia affected was represented by those with the involvement of cervical lymph nodes (75%), the difference compared to the involvement of other chains of ganglia being statistically significant (P=0.0087). All 35 pregnant women with acute toxoplasmosis tested positive for T. gondii-specific IgM antibodies. Most pregnant women with acute T. gondii infection (57.1%) tested negative for T. gondii-specific IgM antibody serum titres within 3-6 months of presentation. The difference compared to other intervals from the moment pregnant women sought care was statistically significant (P= 00002). Only 80% of all pregnant women with acute toxoplasmosis tested positive for T. gondii-specific IgA antibodies. Pregnant women with acute toxoplasmosis have a 3.3 times higher risk of pregnancy loss.

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Coverage and outcomes of antenatal tests for infections: a population based survey in the Province of Trento, Italy

Abstract: Our study indicates that the attention to screening and detecting infected cases is growing over the time. In addition, care delivered during pregnancy has a leading role in determining coverage of the examinations. Immigrant, pluriparous and less educated women need particular attention.

Cited by 16 publications

References 26 publications

Toxoplasma gondii in women of childbearing age and during pregnancy: seroprevalence study in Central and Southern Italy from 2013 to 2017

Toxoplasma gondii in women of childbearing age and during pregnancy: seroprevalence study in Central and Southern Italy from 2013 to 2017

Screening of group B Streptococcus infection in pregnancy and neonatal outcomes in the province of Trento, Italy

Research on demographic, clinical and paraclinical aspects in pregnant women infected with Toxoplasma gondii

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