Coverage and predictors of influenza and pertussis vaccination during pregnancy: a whole of population-based study

Homaira, Nusrat; He, Wen-Qiang; McRae, Jocelynne; Macartney, Kristine; Liu, Bette

doi:10.1016/j.vaccine.2023.09.008

Cited by 4 publications

(1 citation statement)

References 29 publications

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“…A majority of hospitalizations were noted among patients younger than one year (69.2%), which is a consistent finding with the study by Skoff et al 20 There was no fatality during the study period, the fatality rate in our study was lower than that reported in Japanese infants, i.e., 0.15%. 21 Maternal vaccination during pregnancy is an effective intervention to protect against pertussis infection in newborns, 22 , 23 while maternal immunization has not been implemented yet in China. Therefore, it is important supplementary strategy to carry out pertussis vaccine immunization during pregnancy in order to reduce the disease burden and to protect susceptible individuals.…”

Section: Discussionmentioning

confidence: 99%

Economic burden of pertussis in children: A single-center analysis in Hangzhou, China

Liu,

Yang,

Zhou

et al. 2024

Human Vaccines & Immunotherapeutics

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The “reemergence of pertussis” has elicited international concerns, occurring paradoxically amidst the expansion of immunization programs. This study was aimed to evaluate quantitatively the economic burden and identify the determinants that influence the cost associated with treating pertussis in Chinese children. We evaluated the economic burden by Chinese children diagnosed with pertussis at the Children’s Hospital, Zhejiang University School of Medicine in 2022. Direct medical expenses and the utilization of medical resources attributed to pertussis were calculated. A generalized linear regression model was applied to analyze the determinants that were associated with the direct medical expenses among patients. Among the 1110 pertussis patients included in the study, 1060 were outpatients and 50 were inpatients. The average direct medical cost was ¥1878.70(i.e. $279.33). Living in urban areas (OR:1.27, p = .04), complications (OR:1.40, p < .001), hospitalization (OR:10.04, p < .001), and ≥ 3 medical visits (OR:3.71, p < .001) were associated with increased direct medical expenses. Having received four doses of the pertussis vaccine was associated with reduced direct medical expenses (OR:0.81, p = .04). This study underscores a substantial economic burden of pertussis in Hangzhou, with pronounced implications for patients residing in urban areas, experiencing complications, requiring hospitalization, having multiple medical consultations, or lacking comprehensive pertussis vaccination.

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Section: Discussionmentioning

confidence: 99%

Economic burden of pertussis in children: A single-center analysis in Hangzhou, China

Liu,

Yang,

Zhou

et al. 2024

Human Vaccines & Immunotherapeutics

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Efficacy of vaccination during pregnancy in reducing the risk of SARS-CoV-2 infection in infants younger than 12 months. Puglia (Italy), 2021–23

De Virgilio Suglia,

Stefanizzi,

Graziano

et al. 2024

Human Vaccines & Immunotherapeutics

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This retrospective cohort study evaluated the effectiveness of maternal vaccination against COVID-19 in reducing the risk of SARS-CoV-2 infection in infants younger than 12 months. The study, conducted at the “Policlinico” University Hospital of Bari, included 3346 newborns and their mothers. The study explored the degree of protection offered by maternal vaccination depending on the timing, type, and trimester of vaccination, also taking into account the mother’s history of infection. We compared the incidence rate of infection between children of vaccinated and unvaccinated mothers; the values were 10.2% and 18.1%, respectively, and the difference was statistically significant. The overall effectiveness of the vaccine against the infection was 45%. Further analysis revealed increasing efficacy as the doses of vaccine administered to the mother increased and in case of a previous history of maternal infection. Dual immune stimulation (vaccination and natural infection) was 83% effective in preventing infection among newborns. The multivariable models confirmed the protective effect of vaccination with all types of vaccines used. The analysis of infection’s incidence in newborns revealed an interesting temporal trend, with increasing incidence with time, suggesting a possible correlation with the persistence of maternal antibodies or with the gradual weaning. The results on the protective capacity of vaccines are in line with the global literature. Strengths of study include sample size, robust methodology, and multivariate analyses. Institutions could intensify awareness campaigns to encourage both pregnant women and all those who would like to become pregnant to receive SARS-CoV-2 vaccination.

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Global burden of pertussis in 204 countries and territories, from 1990 to 2019: results from the Global Burden of Disease Study 2019

Nie,

Zhang,

Yang

et al. 2024

BMC Public Health

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Objectives This study aimed to examine the impact of pertussis on the global, regional, and national levels between 1990 and 2019. Methods Data on pertussis on a global scale from 1990 to 2019 were collected from the 2019 Global Burden of Disease Study. We performed a secondary analysis to report the global epidemiology and disease burden of pertussis. Results During the period spanning from 1990 to 2019, pertussis exhibited a steady global decline in the age-standardized incidence rate (ASIR), age-standardized disability-adjusted life years rate (ASYR), and age-standardized death rate (ASDR). Nevertheless, upon delving into an in-depth analysis of various regions, it was apparent that ASIR in southern sub-Saharan Africa, ASYR and ASDR in high-income North America, and ASDR in Western Europe and Australasia, were witnessing an upward trajectory. Moreover, a negative correlation was observed between the Socio‑demographic Index (SDI) and burden inflicted by pertussis. Notably, the incidence of pertussis was comparatively lower in men than in women, with 0–4-year-olds emerging as the most profoundly affected demographic. Conclusion The global pertussis burden decreased from 1990 to 2019. However, certain regions and countries faced an increasing disease burden. Therefore, urgent measures are required to alleviate the pertussis burden in these areas.

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Coverage and predictors of influenza and pertussis vaccination during pregnancy: a whole of population-based study

Cited by 4 publications

References 29 publications

Economic burden of pertussis in children: A single-center analysis in Hangzhou, China

Economic burden of pertussis in children: A single-center analysis in Hangzhou, China

Efficacy of vaccination during pregnancy in reducing the risk of SARS-CoV-2 infection in infants younger than 12 months. Puglia (Italy), 2021–23

Global burden of pertussis in 204 countries and territories, from 1990 to 2019: results from the Global Burden of Disease Study 2019

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